Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,648
Total Reports
136
Deaths Reported
370.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 30.8 kg (67.9 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - hookworm 1,322
INEFFECTIVE, HOOKS 874
Digestive tract disorder NOS 528
Diarrhoea 325
Vomiting 244
Lack of efficacy - NOS 212
Lethargy (see also Central nervous system depression in 'Neurological') 170
Lack of efficacy (endoparasite) - NOS 132
Emesis 112
Loose stool 84
Anorexia 71
Other abnormal test result NOS 67
Death by euthanasia 66
Death 65
Panting 61
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 867
Moxidectin 370
Milbemycin Oxime + Praziquantel 310
Imidacloprid + Moxidectin 260
Milbemycin Oxime + Spinosad 246
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 146
Fenbendazole 127
Pyrantel Pamoate;Sarolaner 121
Febantel + Praziquantel + Pyrantel Pamoate 110
Ivermectin, Pyrantel 104
Afoxolaner 89
Milbemycin Oxime 76
Febantel + Praziquantel + Pyrantel 76
Bedinvetmab 73
Carprofen 71
Outcome Breakdown
Outcome Unknown
1,814 (53.4%)
Ongoing
838 (24.6%)
Recovered/Normal
572 (16.8%)
Died
82 (2.4%)
Euthanized
55 (1.6%)
Recovered with Sequela
39 (1.1%)
Gender Distribution
Female 1,908 (52.3%)
Male 1,606 (44.0%)
Unknown 112 (3.1%)
Mixed 22 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 149 | |
| 2011 | 130 | |
| 2012 | 183 | |
| 2013 | 198 | |
| 2014 | 185 | |
| 2015 | 195 | |
| 2016 | 255 | |
| 2017 | 398 | |
| 2018 | 411 | |
| 2019 | 398 | |
| 2020 | 326 | |
| 2021 | 246 | |
| 2022 | 170 | |
| 2023 | 155 | |
| 2024 | 152 | |
| 2025 | 97 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #55 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.