Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
654
Total Reports
20
Deaths Reported
310.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 27.5 kg (60.6 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - hookworm 94
Lack of efficacy (endoparasite) - heartworm 81
Vomiting 78
INEFFECTIVE, HEARTWORM LARVAE 76
Lethargy (see also Central nervous system depression in 'Neurological') 55
Lack of efficacy - NOS 54
Digestive tract disorder NOS 52
Diarrhoea 47
INEFFECTIVE, HOOKS 40
Cardiac disorder NOS 26
INEFFECTIVE, ASCARIDS NOS 22
Seizure NOS 17
Other abnormal test result NOS 16
Lack of efficacy (endoparasite) - whipworm 15
Not eating 14
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 221
Afoxolaner 84
Milbemycin Oxime + Spinosad 31
Milbemycin Oxime, Lufenuron 29
Imidacloprid + Moxidectin 24
Lufenuron + Milbemycin Oxime 23
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 20
Trilostane 20
Prednisone 18
Milbemycin Oxime 17
Melarsomine Dihydrochloride 17
Melarsomine Dihydrochloride Injection 15
Milbemcyin Oxime, Lufenuron, Praziquantel 14
Moxidectin 13
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 13
Outcome Breakdown
Outcome Unknown
380 (57.9%)
Recovered/Normal
136 (20.7%)
Ongoing
82 (12.5%)
Recovered with Sequela
38 (5.8%)
Died
11 (1.7%)
Euthanized
9 (1.4%)
Gender Distribution
Female 332 (50.8%)
Male 312 (47.7%)
Unknown 9 (1.4%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 6 | |
| 2012 | 35 | |
| 2013 | 31 | |
| 2014 | 33 | |
| 2015 | 62 | |
| 2016 | 68 | |
| 2017 | 59 | |
| 2018 | 59 | |
| 2019 | 53 | |
| 2020 | 64 | |
| 2021 | 53 | |
| 2022 | 32 | |
| 2023 | 39 | |
| 2024 | 31 | |
| 2025 | 29 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #123 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.