Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,817
Total Reports
126
Deaths Reported
450.0%
Death Rate
2.8 yr
Avg Age at Report
Average weight at time of report: 31.4 kg (69.2 lbs)
Top Reported Reactions
Vomiting 539
Diarrhoea 331
Lack of efficacy (bacteria) - Borrelia 303
Lack of efficacy (endoparasite) - hookworm 231
Lack of efficacy (ectoparasite) - tick NOS 184
Lethargy (see also Central nervous system depression in 'Neurological') 169
Lack of efficacy (endoparasite) - roundworm NOS 135
Anorexia 110
Other abnormal test result NOS 106
Seizure NOS 104
Lack of efficacy - NOS 102
Lethargy (see also Central nervous system depression in Neurological) 84
Lack of efficacy (bacteria) - NOS 76
Death by euthanasia 75
Panting 74
Most Referenced Drugs
Pyrantel Pamoate;Sarolaner 632
Ivermectin + Pyrantel As Pamoate Salt 355
Afoxolaner 340
Milbemycin Oxime + Praziquantel 209
Milbemycin Oxime + Spinosad 169
Lotilaner 135
Carprofen 111
Moxidectin 98
Oclacitinib Maleate 88
Fluralaner 13.64% 12-Week Chew 84
Sarolaner 76
Bedinvetmab 72
Recombitek Lyme - 2126.R0 70
Fluralaner Chew Tablets 63
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 60
Outcome Breakdown
Ongoing
972 (35.6%)
Outcome Unknown
878 (32.1%)
Recovered/Normal
724 (26.5%)
Euthanized
64 (2.3%)
Died
62 (2.3%)
Recovered with Sequela
31 (1.1%)
Gender Distribution
Male 1,510 (53.6%)
Female 1,227 (43.6%)
Unknown 67 (2.4%)
Mixed 13 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 51 | |
| 2011 | 56 | |
| 2012 | 59 | |
| 2013 | 60 | |
| 2014 | 103 | |
| 2015 | 100 | |
| 2016 | 105 | |
| 2017 | 132 | |
| 2018 | 117 | |
| 2019 | 147 | |
| 2020 | 207 | |
| 2021 | 245 | |
| 2022 | 299 | |
| 2023 | 342 | |
| 2024 | 461 | |
| 2025 | 333 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #65 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.