Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,928
Total Reports
90
Deaths Reported
470.0%
Death Rate
7.5 yr
Avg Age at Report
Average weight at time of report: 8.5 kg (18.7 lbs)
Top Reported Reactions
Vomiting 429
Lethargy (see also Central nervous system depression in 'Neurological') 225
Emesis 207
Diarrhoea 148
Lack of efficacy - NOS 118
Lack of efficacy (ectoparasite) - flea 107
Lack of efficacy (endoparasite) - hookworm 94
Anorexia 84
Seizure NOS 69
Other abnormal test result NOS 68
Behavioural disorder NOS 67
Elevated serum alkaline phosphatase (SAP) 66
INEFFECTIVE, HEARTWORM LARVAE 58
Elevated alanine aminotransferase (ALT) 57
INEFFECTIVE, ASCARIDS NOS 56
Most Referenced Drugs
Milbemycin Oxime + Spinosad 378
Ivermectin + Pyrantel As Pamoate Salt 146
Spinosad 144
Afoxolaner 123
Oclacitinib Maleate 114
Fluralaner Chew Tablets 101
Pyrantel Pamoate;Sarolaner 74
Moxidectin 61
Trilostane 58
Sarolaner 48
Cyclosporine 46
Milbemycin Oxime + Praziquantel 44
Fluralaner 13.64% 12-Week Chew 43
Selamectin 38
Bedinvetmab 38
Outcome Breakdown
Recovered/Normal
667 (38.4%)
Outcome Unknown
499 (28.7%)
Ongoing
408 (23.5%)
Recovered with Sequela
73 (4.2%)
Euthanized
49 (2.8%)
Died
41 (2.4%)
Gender Distribution
Male 968 (50.2%)
Female 929 (48.2%)
Unknown 26 (1.3%)
Mixed 5 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 98 | |
| 2011 | 116 | |
| 2012 | 184 | |
| 2013 | 159 | |
| 2014 | 179 | |
| 2015 | 173 | |
| 2016 | 155 | |
| 2017 | 158 | |
| 2018 | 129 | |
| 2019 | 118 | |
| 2020 | 96 | |
| 2021 | 79 | |
| 2022 | 77 | |
| 2023 | 74 | |
| 2024 | 83 | |
| 2025 | 50 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #81 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.