Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
685
Total Reports
25
Deaths Reported
360.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 22.7 kg (50.1 lbs)
Top Reported Reactions
Vomiting 156
Lethargy (see also Central nervous system depression in 'Neurological') 55
Lack of efficacy (endoparasite) - hookworm 54
Diarrhoea 53
Digestive tract disorder NOS 41
Emesis 39
Lack of efficacy (bacteria) - Borrelia 33
Anorexia 31
Lack of efficacy - NOS 28
INEFFECTIVE, ASCARIDS NOS 26
Lack of efficacy (ectoparasite) - tick NOS 26
Lack of efficacy (bacteria) - NOS 22
Lack of efficacy (endoparasite) - roundworm NOS 22
Other abnormal test result NOS 21
Ataxia 20
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 90
Afoxolaner 72
Milbemycin Oxime + Spinosad 70
Pyrantel Pamoate;Sarolaner 69
Oclacitinib Maleate 35
Fluralaner Chew Tablets 33
Milbemycin Oxime + Praziquantel 30
Spinosad 24
Sarolaner 23
Carprofen 21
Fluralaner 13.64% 12-Week Chew 17
Selamectin 16
Bedinvetmab 16
Milbemycin Oxime 13
Moxidectin 12
Outcome Breakdown
Outcome Unknown
222 (35.0%)
Recovered/Normal
196 (30.9%)
Ongoing
178 (28.0%)
Recovered with Sequela
14 (2.2%)
Euthanized
13 (2.0%)
Died
12 (1.9%)
Gender Distribution
Male 355 (51.8%)
Female 317 (46.3%)
Unknown 9 (1.3%)
Mixed 4 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 24 | |
| 2011 | 28 | |
| 2012 | 45 | |
| 2013 | 39 | |
| 2014 | 42 | |
| 2015 | 45 | |
| 2016 | 59 | |
| 2017 | 54 | |
| 2018 | 54 | |
| 2019 | 40 | |
| 2020 | 39 | |
| 2021 | 44 | |
| 2022 | 38 | |
| 2023 | 41 | |
| 2024 | 48 | |
| 2025 | 45 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #122 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.