Total Reports
262
FDA CVM filings
Dog /
FDA CVM · 2025 release 262 reports on file
Shepherd Dog - Dutch - FDA Adverse Event Profile
Adverse-event records for Shepherd Dog - Dutch (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Shepherd Dog - Dutch ranks #172 by report volume among dog breeds - 3 of 262 reports (1.1%) recorded a death outcome.
- #172
- most-reported dog breed
- 1.1%
- death-coded report share
- 53
- Lack of efficacy (endoparasite) - heartworm - top reaction
- 4.2 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
3
of 262 reports
Death Rate
1.1%
death-coded share
Avg Age at Report
4.2 yr
29.8 kg avg weight
Death-Coded Outcome Share
Shepherd Dog - Dutch death-coded reports 1.1%
Cross-breed median
1.1% of 262 shepherd dog - dutch reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 29.8 kg (65.7 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 53
Vomiting 51
INEFFECTIVE, HEARTWORM LARVAE 23
Lethargy (see also Central nervous system depression in 'Neurological') 16
Diarrhoea 15
Emesis 10
Lack of efficacy (endoparasite) - hookworm 10
Lack of efficacy (ectoparasite) - tick NOS 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 41
Ivermectin + Pyrantel As Pamoate Salt 40
Moxidectin 30
Pyrantel Pamoate;Sarolaner 23
Milbemycin Oxime + Praziquantel 15
Afoxolaner 14
Bedinvetmab 12
Sarolaner 11
Outcome Breakdown
Ongoing
86 (34.1%)
Outcome Unknown
83 (32.9%)
Recovered/Normal
66 (26.2%)
Recovered with Sequela
14 (5.6%)
Died
3 (1.2%)
Gender Distribution
Male 150 (57.3%)
Female 109 (41.6%)
Unknown 2 (0.8%)
Mixed 1 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 4 | |
| 2011 | 6 | |
| 2012 | 8 | |
| 2013 | 10 | |
| 2014 | 8 | |
| 2015 | 13 | |
| 2016 | 17 | |
| 2017 | 19 | |
| 2018 | 12 | |
| 2019 | 18 | |
| 2020 | 31 | |
| 2021 | 18 | |
| 2022 | 16 | |
| 2023 | 30 | |
| 2024 | 33 | |
| 2025 | 19 | |
Shepherd Dog - Dutch Pet Health Insights
Shepherd Dog - Dutch accounts for 262 FDA adverse event reports, ranking #172 by volume among dog breeds, with 3 reports (1.1%) coded as a death outcome. Mean age at report: 4.2 years, average weight 29.8 kg (65.7 lbs).
Top reported signs: Lack of efficacy (endoparasite) - heartworm (53), Vomiting (51), INEFFECTIVE, HEARTWORM LARVAE (23). Most-referenced drug: Milbemycin Oxime + Spinosad (41 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (40) and Moxidectin (30).
Outcome coding on 252 status-recorded reports is dominated by Ongoing (34.1%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Irish Wolfhound
277 reports · 7.2% death rate
Retriever - Nova Scotia Duck Tolling
240 reports · 1.7% death rate
Cattle Dog - Flanders (Bouvier)
287 reports · 7.0% death rate
Foxhound - American
291 reports · 3.4% death rate
Terrier - Norwich
232 reports · 3.0% death rate
Setter - Gordon
227 reports · 5.3% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Shepherd Dog - Dutch? ▼
There are 262 adverse event reports involving Shepherd Dog - Dutch in the FDA database, with 3 reports involving death (1.1% death rate). Shepherd Dog - Dutch ranks #172 by report volume.
What are the most common adverse reactions reported for Shepherd Dog - Dutch? ▼
The most commonly reported adverse reactions for Shepherd Dog - Dutch are Lack of efficacy (endoparasite) - heartworm (53 reports), Vomiting (51 reports), INEFFECTIVE, HEARTWORM LARVAE (23 reports), Lethargy (see also Central nervous system depression in 'Neurological') (16 reports), Diarrhoea (15 reports).
What drugs are most frequently associated with Shepherd Dog - Dutch adverse events? ▼
The drugs most frequently referenced in Shepherd Dog - Dutch adverse event reports are Milbemycin Oxime + Spinosad (41 reports), Ivermectin + Pyrantel As Pamoate Salt (40 reports), Moxidectin (30 reports), Pyrantel Pamoate;Sarolaner (23 reports), Milbemycin Oxime + Praziquantel (15 reports).
What is the average age of Shepherd Dog - Dutch in adverse event reports? ▼
The average age of Shepherd Dog - Dutch at the time of adverse event reports is 4.2 years, with an average weight of 29.8 kg (65.7 lbs).
Does a high number of adverse event reports mean Shepherd Dog - Dutch is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shepherd Dog - Dutch safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.