Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
262
Total Reports
3
Deaths Reported
110.0%
Death Rate
4.2 yr
Avg Age at Report
Average weight at time of report: 29.8 kg (65.7 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 53
Vomiting 51
INEFFECTIVE, HEARTWORM LARVAE 23
Lethargy (see also Central nervous system depression in 'Neurological') 16
Diarrhoea 15
Emesis 10
Lack of efficacy (endoparasite) - hookworm 10
Lack of efficacy (ectoparasite) - tick NOS 10
Lack of efficacy - NOS 9
Lack of efficacy (endoparasite) - roundworm NOS 9
Seizure NOS 8
Anorexia 7
Cardiac disorder NOS 7
Panting 7
Not eating 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 41
Ivermectin + Pyrantel As Pamoate Salt 40
Moxidectin 30
Pyrantel Pamoate;Sarolaner 23
Milbemycin Oxime + Praziquantel 15
Afoxolaner 14
Bedinvetmab 12
Sarolaner 11
Fluralaner Chew Tablets 9
Spinosad 7
Oclacitinib Maleate 7
Melarsomine Dihydrochloride 6
Ivermectin 6
Fluralaner 13.64% 12-Week Chew 6
Carprofen 5
Outcome Breakdown
Ongoing
86 (34.1%)
Outcome Unknown
83 (32.9%)
Recovered/Normal
66 (26.2%)
Recovered with Sequela
14 (5.6%)
Died
3 (1.2%)
Gender Distribution
Male 150 (57.3%)
Female 109 (41.6%)
Unknown 2 (0.8%)
Mixed 1 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 4 | |
| 2011 | 6 | |
| 2012 | 8 | |
| 2013 | 10 | |
| 2014 | 8 | |
| 2015 | 13 | |
| 2016 | 17 | |
| 2017 | 19 | |
| 2018 | 12 | |
| 2019 | 18 | |
| 2020 | 31 | |
| 2021 | 18 | |
| 2022 | 16 | |
| 2023 | 30 | |
| 2024 | 33 | |
| 2025 | 19 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #172 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.