Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
310
Total Reports
9
Deaths Reported
290.0%
Death Rate
4.1 yr
Avg Age at Report
Average weight at time of report: 26.9 kg (59.3 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 59
Vomiting 48
Lack of efficacy (endoparasite) - hookworm 30
Diarrhoea 22
Emesis 20
Lethargy (see also Central nervous system depression in 'Neurological') 19
Digestive tract disorder NOS 17
INEFFECTIVE, HOOKS 14
Lack of efficacy (bacteria) - Borrelia 14
Lack of efficacy (endoparasite) - roundworm NOS 11
Lack of efficacy - NOS 10
Lack of efficacy (endoparasite) - whipworm 9
INEFFECTIVE, HEARTWORM LARVAE 9
Other abnormal test result NOS 9
Not eating 9
Most Referenced Drugs
Milbemycin Oxime + Spinosad 61
Pyrantel Pamoate;Sarolaner 56
Milbemycin Oxime + Praziquantel 46
Ivermectin + Pyrantel As Pamoate Salt 36
Moxidectin 25
Sarolaner 14
Afoxolaner 12
Gabapentin 11
Fluralaner Chew Tablets 10
Bedinvetmab 10
Lotilaner 9
Melarsomine Dihydrochloride 8
Ivermectin + Pyrantel 7
Prednisone 7
Milbemycin Oxime 7
Outcome Breakdown
Ongoing
114 (36.8%)
Outcome Unknown
109 (35.2%)
Recovered/Normal
64 (20.6%)
Recovered with Sequela
14 (4.5%)
Euthanized
6 (1.9%)
Died
3 (1.0%)
Gender Distribution
Female 160 (51.6%)
Male 148 (47.7%)
Unknown 2 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 3 | |
| 2012 | 9 | |
| 2013 | 11 | |
| 2014 | 16 | |
| 2015 | 12 | |
| 2016 | 12 | |
| 2017 | 14 | |
| 2018 | 33 | |
| 2019 | 27 | |
| 2020 | 33 | |
| 2021 | 23 | |
| 2022 | 37 | |
| 2023 | 25 | |
| 2024 | 42 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #165 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.