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Breed profile · FDA CVM July 2026 extract

Setter - Irish Red adverse-event record

Adverse-event filings for Setter - Irish Red (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#125 of 510
by report volume (all breeds)
665
FDA CVM reports on file
3.8%
death-coded share of reports
#190 of 275
by death-coded share (≥50 reports)

How the 665 reports break down

By recorded gender -- every report on file for Setter - Irish Red, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 61 45.75 30.5 15.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Setter - Irish Red drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Setter - Irish Red ranks #125 of 510 by total reports (665) and #190 of 275 by death-coded share (3.8%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#125
This breed, reports of 510
#190
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Setter - Irish Red has 665 reports now versus 654 in that prior snapshot: 11 more (1.7%).

Report change
+11
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Setter - Irish Red changes

Total Reports

665

High report volume

Deaths Reported

25

of 665 reports

Death-coded share of reports

3.8%

Below-median death-coded share

Avg Age at Report

5.2 yr

27.9 kg avg weight

Breed Safety Scorecard

C (56/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate B
3.8%

Share of reports coded as a fatality

Euthanasia rate C
2.0%

Share of reports resulting in euthanasia

Full recovery rate F
26.0%

Share of reports coded "Recovered/Normal"

5-year trend D
+12%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Setter - Irish Red death-coded reports 3.8%
Cross-breed median

3.8% of 665 setter - irish red reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Setter - Irish Red's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

4% 31st percentile Higher share than 31% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Setter - Irish Red 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 27.9 kg (61.5 lbs)

Top Reported Reactions

Vomiting 135
Diarrhoea 44
Lethargy (see also Central nervous system depression in 'Neurological') 41
Lack of efficacy (endoparasite) - hookworm 39
Seizure NOS 37
Lack of efficacy - NOS 34
Lack of efficacy (ectoparasite) - tick NOS 29
Emesis 27

Most Referenced Drugs

Ivermectin + Pyrantel As Pamoate Salt 81
Milbemycin Oxime + Spinosad 76
Afoxolaner 68
Pyrantel Pamoate;Sarolaner 67
Fluralaner Chew Tablets 40
Moxidectin 33
Milbemycin Oxime + Praziquantel 31
Carprofen 30

Outcome Breakdown

Outcome Unknown
205 (33.3%)
Ongoing
185 (30.1%)
Recovered/Normal
173 (28.1%)
Recovered with Sequela
27 (4.4%)
Euthanized
13 (2.1%)
Died
12 (2.0%)

Gender Distribution

Male 349 (52.5%)
Female 304 (45.7%)
Unknown 11 (1.7%)
Mixed 1 (0.2%)

Reports by Year

Year Reports Trend
2010 26
2011 23
2012 30
2013 29
2014 34
2015 37
2016 43
2017 50
2018 51
2019 43
2020 52
2021 42
2022 49
2023 37
2024 61
2025 47
2026 11

Setter - Irish Red: low death-coded share in the FDA CVM extract

Signature read: 665 reports place Setter - Irish Red in the upper third of breed filing volume (#125 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Setter - Irish Red sits at #125 of 510 by report volume among all breeds and #105 of 298 among dog breeds, with 665 reports and 25 (3.8%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #190 of 275. Mean age at report: 5.2 years, average weight 27.9 kg (61.5 lbs).

Top reported signs: Vomiting (135), Diarrhoea (44), Lethargy (see also Central nervous system depression in 'Neurological') (41). Most-referenced drug: Ivermectin + Pyrantel As Pamoate Salt (81 reports), followed by Milbemycin Oxime + Spinosad (76) and Afoxolaner (68).

Outcome coding on 615 status-recorded reports is dominated by Outcome Unknown (33.3%). Annual submissions ranged 11-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Coonhound - Black and Tan
674 reports · 3.3% death-coded
Dachshund - Standard Smooth-haired
636 reports · 8.2% death-coded
Griffon - Brussels
627 reports · 5.3% death-coded
Corso Dog
620 reports · 4.2% death-coded
Portuguese Water Dog
718 reports · 3.6% death-coded
Black Mouth Cur
592 reports · 2.0% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Setter - Irish Red drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (3.8% death-coded here).

British cat 3.8% · Cat American Curl Shorthair 3.5% · Cat Siberian 4.2% · Cat Oriental 3.1% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (27.9 kg here).

Mixed (Sheep) 24.9 kg · Sheep Fish (other) 32.4 kg · Fish Katahdin 32.4 kg · Sheep Nubian 32.8 kg · Goat

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Setter - Irish Red? ▼
There are 665 adverse event reports involving Setter - Irish Red in the FDA database, of which 25 were death-coded (3.8% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Setter - Irish Red ranks #125 of 510 by report volume among all breeds PlainBreed indexes (#105 of 298 among dog breeds).
Where does Setter - Irish Red sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Setter - Irish Red is #125 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #105 of 298. Among breeds with at least 50 reports, its death-coded share ranks #190 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Setter - Irish Red? ▼
The most commonly reported adverse reactions for Setter - Irish Red are Vomiting (135 reports), Diarrhoea (44 reports), Lethargy (see also Central nervous system depression in 'Neurological') (41 reports), Lack of efficacy (endoparasite) - hookworm (39 reports), Seizure NOS (37 reports).
What drugs are most frequently associated with Setter - Irish Red adverse events? ▼
The drugs most frequently referenced in Setter - Irish Red adverse event reports are Ivermectin + Pyrantel As Pamoate Salt (81 reports), Milbemycin Oxime + Spinosad (76 reports), Afoxolaner (68 reports), Pyrantel Pamoate;Sarolaner (67 reports), Fluralaner Chew Tablets (40 reports).
What is the average age of Setter - Irish Red in adverse event reports? ▼
The average age of Setter - Irish Red at the time of adverse event reports is 5.2 years, with an average weight of 27.9 kg (61.5 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Setter - Irish Red (Dog), extract as of July 2026 extract. 665 reports · 25 death-coded (3.8% of reports, not a mortality rate) · #125 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →