Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
640
Total Reports
25
Deaths Reported
390.0%
Death Rate
5.2 yr
Avg Age at Report
Average weight at time of report: 27.8 kg (61.3 lbs)
Top Reported Reactions
Vomiting 134
Diarrhoea 44
Lethargy (see also Central nervous system depression in 'Neurological') 41
Lack of efficacy (endoparasite) - hookworm 38
Lack of efficacy - NOS 34
Seizure NOS 34
Lack of efficacy (ectoparasite) - tick NOS 29
Emesis 27
INEFFECTIVE, HEARTWORM LARVAE 26
Digestive tract disorder NOS 26
Anorexia 25
Lack of efficacy (endoparasite) - roundworm NOS 25
Not eating 23
Lack of efficacy (endoparasite) - heartworm 23
Lack of efficacy (bacteria) - Borrelia 22
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 80
Milbemycin Oxime + Spinosad 75
Afoxolaner 66
Pyrantel Pamoate;Sarolaner 57
Fluralaner Chew Tablets 40
Moxidectin 31
Milbemycin Oxime + Praziquantel 29
Carprofen 26
Fluralaner 13.64% 12-Week Chew 21
Bedinvetmab 21
Spinosad 17
Oclacitinib Maleate 17
Selamectin 15
Milbemycin 14
Firocoxib 12
Outcome Breakdown
Outcome Unknown
201 (34.1%)
Ongoing
172 (29.2%)
Recovered/Normal
165 (28.0%)
Recovered with Sequela
27 (4.6%)
Euthanized
13 (2.2%)
Died
12 (2.0%)
Gender Distribution
Male 332 (51.9%)
Female 296 (46.3%)
Unknown 11 (1.7%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 26 | |
| 2011 | 23 | |
| 2012 | 30 | |
| 2013 | 29 | |
| 2014 | 34 | |
| 2015 | 37 | |
| 2016 | 43 | |
| 2017 | 50 | |
| 2018 | 51 | |
| 2019 | 43 | |
| 2020 | 52 | |
| 2021 | 42 | |
| 2022 | 49 | |
| 2023 | 37 | |
| 2024 | 61 | |
| 2025 | 33 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #125 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.