Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,645
Total Reports
107
Deaths Reported
230.0%
Death Rate
4.1 yr
Avg Age at Report
Average weight at time of report: 24.9 kg (54.9 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 860
Vomiting 640
Lack of efficacy (endoparasite) - hookworm 552
INEFFECTIVE, HOOKS 269
INEFFECTIVE, HEARTWORM LARVAE 260
Lethargy (see also Central nervous system depression in 'Neurological') 253
Emesis 250
Lack of efficacy - NOS 247
Digestive tract disorder NOS 237
Diarrhoea 219
Seizure NOS 147
Other abnormal test result NOS 114
Lack of efficacy (endoparasite) - roundworm NOS 114
Lack of efficacy (ectoparasite) - flea 107
Lack of efficacy (ectoparasite) - tick NOS 106
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 1,094
Milbemycin Oxime + Spinosad 726
Pyrantel Pamoate;Sarolaner 464
Milbemycin Oxime + Praziquantel 434
Moxidectin 369
Afoxolaner 315
Melarsomine Dihydrochloride 192
Sarolaner 138
Oclacitinib Maleate 135
Spinosad 114
Ivermectin 102
Bedinvetmab 96
Carprofen 77
Milbemycin Oxime, Lufenuron 68
Lufenuron + Milbemycin Oxime 67
Outcome Breakdown
Outcome Unknown
1,876 (40.4%)
Ongoing
1,347 (29.0%)
Recovered/Normal
1,045 (22.5%)
Recovered with Sequela
273 (5.9%)
Died
55 (1.2%)
Euthanized
52 (1.1%)
Gender Distribution
Male 2,326 (50.1%)
Female 2,265 (48.8%)
Unknown 40 (0.9%)
Mixed 14 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 4 | |
| 2011 | 60 | |
| 2012 | 153 | |
| 2013 | 177 | |
| 2014 | 217 | |
| 2015 | 252 | |
| 2016 | 305 | |
| 2017 | 364 | |
| 2018 | 394 | |
| 2019 | 469 | |
| 2020 | 468 | |
| 2021 | 450 | |
| 2022 | 339 | |
| 2023 | 358 | |
| 2024 | 402 | |
| 2025 | 233 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #41 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.