Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,321
Total Reports
61
Deaths Reported
460.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 25.1 kg (55.3 lbs)
Top Reported Reactions
Vomiting 251
Emesis 106
Diarrhoea 105
Lack of efficacy - NOS 93
Lethargy (see also Central nervous system depression in 'Neurological') 88
Lack of efficacy (ectoparasite) - flea 79
Lack of efficacy (endoparasite) - heartworm 73
Lack of efficacy (endoparasite) - hookworm 71
INEFFECTIVE, HEARTWORM LARVAE 69
Digestive tract disorder NOS 46
Seizure NOS 46
Anorexia 41
Ataxia 40
Behavioural disorder NOS 36
Other abnormal test result NOS 36
Most Referenced Drugs
Milbemycin Oxime + Spinosad 262
Ivermectin + Pyrantel As Pamoate Salt 151
Afoxolaner 87
Spinosad 80
Pyrantel Pamoate;Sarolaner 76
Moxidectin 72
Milbemycin Oxime + Praziquantel 51
Oclacitinib Maleate 46
Carprofen 42
Fluralaner Chew Tablets 41
Trilostane 40
Bedinvetmab 32
Sarolaner 29
Fluralaner 13.64% 12-Week Chew 28
Gabapentin 22
Outcome Breakdown
Outcome Unknown
424 (34.6%)
Recovered/Normal
388 (31.7%)
Ongoing
296 (24.2%)
Recovered with Sequela
55 (4.5%)
Died
38 (3.1%)
Euthanized
23 (1.9%)
Gender Distribution
Female 703 (53.2%)
Male 578 (43.8%)
Unknown 36 (2.7%)
Mixed 4 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 52 | |
| 2011 | 73 | |
| 2012 | 100 | |
| 2013 | 89 | |
| 2014 | 98 | |
| 2015 | 112 | |
| 2016 | 100 | |
| 2017 | 102 | |
| 2018 | 86 | |
| 2019 | 75 | |
| 2020 | 88 | |
| 2021 | 62 | |
| 2022 | 61 | |
| 2023 | 83 | |
| 2024 | 86 | |
| 2025 | 54 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #93 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.