Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,837
Total Reports
49
Deaths Reported
270.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 18.9 kg (41.7 lbs)
Top Reported Reactions
Vomiting 275
Lack of efficacy (endoparasite) - hookworm 184
Lack of efficacy (endoparasite) - heartworm 153
INEFFECTIVE, HEARTWORM LARVAE 134
Emesis 117
Digestive tract disorder NOS 114
Lethargy (see also Central nervous system depression in 'Neurological') 108
Lack of efficacy - NOS 98
INEFFECTIVE, ASCARIDS NOS 80
Diarrhoea 75
Lack of efficacy (ectoparasite) - tick NOS 57
Seizure NOS 56
Lack of efficacy (endoparasite) - roundworm NOS 51
Lack of efficacy (ectoparasite) - flea 50
INEFFECTIVE, HOOKS 50
Most Referenced Drugs
Milbemycin Oxime + Spinosad 316
Ivermectin + Pyrantel As Pamoate Salt 204
Milbemycin Oxime + Praziquantel 145
Pyrantel Pamoate;Sarolaner 129
Moxidectin 115
Fluralaner Chew Tablets 74
Spinosad 73
Carprofen 66
Fluralaner 13.64% 12-Week Chew 66
Ivermectin, Pyrantel 64
Trilostane 61
Lotilaner 57
Afoxolaner 54
Sarolaner 44
Oclacitinib Maleate 42
Outcome Breakdown
Outcome Unknown
577 (35.4%)
Ongoing
498 (30.6%)
Recovered/Normal
421 (25.9%)
Recovered with Sequela
83 (5.1%)
Died
27 (1.7%)
Euthanized
22 (1.4%)
Gender Distribution
Female 922 (50.2%)
Male 886 (48.2%)
Unknown 23 (1.3%)
Mixed 6 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 105 | |
| 2011 | 115 | |
| 2012 | 122 | |
| 2013 | 129 | |
| 2014 | 106 | |
| 2015 | 97 | |
| 2016 | 105 | |
| 2017 | 117 | |
| 2018 | 112 | |
| 2019 | 144 | |
| 2020 | 97 | |
| 2021 | 98 | |
| 2022 | 127 | |
| 2023 | 123 | |
| 2024 | 146 | |
| 2025 | 94 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #82 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.