Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
317
Total Reports
10
Deaths Reported
320.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 9.2 kg (20.3 lbs)
Top Reported Reactions
Vomiting 77
Emesis 43
Lethargy (see also Central nervous system depression in 'Neurological') 32
Diarrhoea 30
Lack of efficacy (endoparasite) - hookworm 18
Anorexia 16
Lack of efficacy (ectoparasite) - flea 15
Digestive tract disorder NOS 15
Seizure NOS 12
Other abnormal test result NOS 12
Ataxia 11
Polyuria 10
Elevated serum alkaline phosphatase (SAP) 10
Polydipsia 10
Shaking 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 64
Afoxolaner 28
Trilostane 25
Ivermectin + Pyrantel As Pamoate Salt 23
Spinosad 21
Pyrantel Pamoate;Sarolaner 20
Oclacitinib Maleate 11
Fluralaner Chew Tablets 11
Milbemycin Oxime + Praziquantel 10
Fluralaner 13.64% 12-Week Chew 10
Moxidectin 8
Sarolaner 8
Lotilaner 8
Carprofen 7
Bedinvetmab 7
Outcome Breakdown
Recovered/Normal
118 (38.3%)
Outcome Unknown
105 (34.1%)
Ongoing
69 (22.4%)
Died
6 (1.9%)
Recovered with Sequela
6 (1.9%)
Euthanized
4 (1.3%)
Gender Distribution
Male 164 (51.7%)
Female 151 (47.6%)
Unknown 2 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 5 | |
| 2011 | 8 | |
| 2012 | 35 | |
| 2013 | 27 | |
| 2014 | 27 | |
| 2015 | 26 | |
| 2016 | 28 | |
| 2017 | 21 | |
| 2018 | 19 | |
| 2019 | 23 | |
| 2020 | 19 | |
| 2021 | 17 | |
| 2022 | 11 | |
| 2023 | 13 | |
| 2024 | 21 | |
| 2025 | 17 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #164 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.