Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
757
Total Reports
20
Deaths Reported
260.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 6.3 kg (13.9 lbs)
Top Reported Reactions
Vomiting 239
Lethargy (see also Central nervous system depression in 'Neurological') 90
Diarrhoea 87
Emesis 65
Lack of efficacy (ectoparasite) - flea 43
Emesis (multiple) 31
Anorexia 29
Behavioural disorder NOS 26
Not eating 26
Seizure NOS 26
Other abnormal test result NOS 25
Lack of efficacy - NOS 24
Lack of efficacy (endoparasite) - hookworm 23
Panting 21
Elevated alanine aminotransferase (ALT) 20
Most Referenced Drugs
Milbemycin Oxime + Spinosad 157
Fluralaner Chew Tablets 60
Pyrantel Pamoate;Sarolaner 57
Spinosad 50
Ivermectin + Pyrantel As Pamoate Salt 48
Moxidectin 42
Fluralaner 13.64% 12-Week Chew 35
Afoxolaner 32
Oclacitinib Maleate 29
Sarolaner 28
Milbemycin Oxime + Praziquantel 23
Carprofen 19
Selamectin 17
Lufenuron + Milbemycin Oxime 11
Grapiprant 10
Outcome Breakdown
Recovered/Normal
317 (44.0%)
Ongoing
185 (25.7%)
Outcome Unknown
173 (24.0%)
Recovered with Sequela
26 (3.6%)
Died
11 (1.5%)
Euthanized
9 (1.2%)
Gender Distribution
Male 380 (50.2%)
Female 366 (48.3%)
Unknown 10 (1.3%)
Mixed 1 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 15 | |
| 2011 | 26 | |
| 2012 | 53 | |
| 2013 | 69 | |
| 2014 | 57 | |
| 2015 | 38 | |
| 2016 | 56 | |
| 2017 | 58 | |
| 2018 | 56 | |
| 2019 | 46 | |
| 2020 | 50 | |
| 2021 | 55 | |
| 2022 | 41 | |
| 2023 | 60 | |
| 2024 | 49 | |
| 2025 | 28 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #118 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.