Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,104
Total Reports
63
Deaths Reported
570.0%
Death Rate
7.8 yr
Avg Age at Report
Average weight at time of report: 7.3 kg (16.1 lbs)
Top Reported Reactions
Vomiting 205
Lethargy (see also Central nervous system depression in 'Neurological') 140
Emesis 110
Diarrhoea 96
Lack of efficacy (ectoparasite) - flea 75
Lack of efficacy - NOS 70
Elevated serum alkaline phosphatase (SAP) 66
Elevated alanine aminotransferase (ALT) 57
Seizure NOS 55
Underdose 48
Hyperkalaemia 46
Anorexia 45
Decreased appetite 42
Other abnormal test result NOS 39
Weight loss 38
Most Referenced Drugs
Trilostane 399
Milbemycin Oxime + Spinosad 221
Moxidectin 87
Spinosad 71
Pyrantel Pamoate;Sarolaner 68
Fluralaner Chew Tablets 48
Carprofen 37
Sarolaner 36
Oclacitinib Maleate 35
Fluralaner 13.64% 12-Week Chew 29
Maropitant Citrate 27
Milbemycin Oxime + Praziquantel 22
Selamectin 20
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 19
Gabapentin 15
Outcome Breakdown
Recovered/Normal
383 (34.7%)
Outcome Unknown
350 (31.7%)
Ongoing
290 (26.3%)
Euthanized
37 (3.4%)
Died
26 (2.4%)
Recovered with Sequela
18 (1.6%)
Gender Distribution
Male 564 (51.1%)
Female 520 (47.1%)
Unknown 17 (1.5%)
Mixed 3 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2011 | 9 | |
| 2012 | 80 | |
| 2013 | 90 | |
| 2014 | 69 | |
| 2015 | 57 | |
| 2016 | 82 | |
| 2017 | 68 | |
| 2018 | 102 | |
| 2019 | 103 | |
| 2020 | 110 | |
| 2021 | 79 | |
| 2022 | 62 | |
| 2023 | 71 | |
| 2024 | 70 | |
| 2025 | 50 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #106 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.