Total Reports
4,227
FDA CVM filings
Dog /
FDA CVM · 2025 release 4,227 reports on file
Deutsche Dogge, Great Dane - FDA Adverse Event Profile
Adverse-event records for Deutsche Dogge, Great Dane (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Deutsche Dogge, Great Dane ranks #47 by report volume among dog breeds - 255 of 4,227 reports (6.0%) recorded a death outcome.
- #47
- most-reported dog breed
- 6.0%
- death-coded report share
- 808
- Vomiting - top reaction
- 3.5 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
255
of 4,227 reports
Death Rate
6.0%
death-coded share
Avg Age at Report
3.5 yr
49.7 kg avg weight
Death-Coded Outcome Share
Deutsche Dogge, Great Dane death-coded reports 6.0%
Cross-breed median
6.0% of 4,227 deutsche dogge, great dane reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 49.7 kg (109.6 lbs)
Top Reported Reactions
Vomiting 808
Diarrhoea 425
Emesis 349
Lack of efficacy (endoparasite) - heartworm 328
Lethargy (see also Central nervous system depression in 'Neurological') 293
INEFFECTIVE, HEARTWORM LARVAE 237
Lack of efficacy - NOS 237
Lack of efficacy (endoparasite) - hookworm 218
Lack of efficacy (ectoparasite) - flea 158
Anorexia 142
Death 138
Underdose 138
Seizure NOS 130
Weight loss 128
Other abnormal test result NOS 116
Most Referenced Drugs
Milbemycin Oxime + Spinosad 965
Ivermectin + Pyrantel As Pamoate Salt 640
Moxidectin 356
Milbemycin Oxime + Praziquantel 298
Pyrantel Pamoate;Sarolaner 281
Afoxolaner 240
Spinosad 200
Fluralaner Chew Tablets 199
Carprofen 193
Bedinvetmab 131
Fluralaner 13.64% 12-Week Chew 126
Sarolaner 104
Oclacitinib Maleate 98
Melarsomine Dihydrochloride 77
Imidacloprid + Moxidectin 72
Outcome Breakdown
Outcome Unknown
1,238 (31.4%)
Recovered/Normal
1,207 (30.6%)
Ongoing
1,119 (28.4%)
Died
166 (4.2%)
Recovered with Sequela
121 (3.1%)
Euthanized
89 (2.3%)
Gender Distribution
Male 2,138 (50.6%)
Female 1,940 (45.9%)
Unknown 128 (3.0%)
Mixed 21 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 176 | |
| 2011 | 188 | |
| 2012 | 253 | |
| 2013 | 273 | |
| 2014 | 260 | |
| 2015 | 247 | |
| 2016 | 298 | |
| 2017 | 288 | |
| 2018 | 299 | |
| 2019 | 354 | |
| 2020 | 301 | |
| 2021 | 248 | |
| 2022 | 294 | |
| 2023 | 283 | |
| 2024 | 287 | |
| 2025 | 178 | |
Deutsche Dogge, Great Dane Pet Health Insights
Deutsche Dogge, Great Dane accounts for 4,227 FDA adverse event reports, ranking #47 by volume among dog breeds, with 255 reports (6.0%) coded as a death outcome. Mean age at report: 3.5 years, average weight 49.7 kg (109.6 lbs).
Top reported signs: Vomiting (808), Diarrhoea (425), Emesis (349). Most-referenced drug: Milbemycin Oxime + Spinosad (965 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (640) and Moxidectin (356).
Outcome coding on 3,940 status-recorded reports is dominated by Outcome Unknown (31.4%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Terrier - West Highland White
4,266 reports · 4.9% death rate
Great Pyrenees
4,292 reports · 3.8% death rate
Dachshund - Miniature
4,095 reports · 4.6% death rate
Poodle - Toy
4,084 reports · 4.0% death rate
Sheepdog - Shetland
4,080 reports · 6.6% death rate
Poodle - Standard
4,455 reports · 3.1% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Deutsche Dogge, Great Dane? ▼
There are 4,227 adverse event reports involving Deutsche Dogge, Great Dane in the FDA database, with 255 reports involving death (6.0% death rate). Deutsche Dogge, Great Dane ranks #47 by report volume.
What are the most common adverse reactions reported for Deutsche Dogge, Great Dane? ▼
The most commonly reported adverse reactions for Deutsche Dogge, Great Dane are Vomiting (808 reports), Diarrhoea (425 reports), Emesis (349 reports), Lack of efficacy (endoparasite) - heartworm (328 reports), Lethargy (see also Central nervous system depression in 'Neurological') (293 reports).
What drugs are most frequently associated with Deutsche Dogge, Great Dane adverse events? ▼
The drugs most frequently referenced in Deutsche Dogge, Great Dane adverse event reports are Milbemycin Oxime + Spinosad (965 reports), Ivermectin + Pyrantel As Pamoate Salt (640 reports), Moxidectin (356 reports), Milbemycin Oxime + Praziquantel (298 reports), Pyrantel Pamoate;Sarolaner (281 reports).
What is the average age of Deutsche Dogge, Great Dane in adverse event reports? ▼
The average age of Deutsche Dogge, Great Dane at the time of adverse event reports is 3.5 years, with an average weight of 49.7 kg (109.6 lbs).
Does a high number of adverse event reports mean Deutsche Dogge, Great Dane is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Deutsche Dogge, Great Dane safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.