Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,227
Total Reports
255
Deaths Reported
600.0%
Death Rate
3.5 yr
Avg Age at Report
Average weight at time of report: 49.7 kg (109.6 lbs)
Top Reported Reactions
Vomiting 808
Diarrhoea 425
Emesis 349
Lack of efficacy (endoparasite) - heartworm 328
Lethargy (see also Central nervous system depression in 'Neurological') 293
INEFFECTIVE, HEARTWORM LARVAE 237
Lack of efficacy - NOS 237
Lack of efficacy (endoparasite) - hookworm 218
Lack of efficacy (ectoparasite) - flea 158
Anorexia 142
Death 138
Underdose 138
Seizure NOS 130
Weight loss 128
Other abnormal test result NOS 116
Most Referenced Drugs
Milbemycin Oxime + Spinosad 965
Ivermectin + Pyrantel As Pamoate Salt 640
Moxidectin 356
Milbemycin Oxime + Praziquantel 298
Pyrantel Pamoate;Sarolaner 281
Afoxolaner 240
Spinosad 200
Fluralaner Chew Tablets 199
Carprofen 193
Bedinvetmab 131
Fluralaner 13.64% 12-Week Chew 126
Sarolaner 104
Oclacitinib Maleate 98
Melarsomine Dihydrochloride 77
Imidacloprid + Moxidectin 72
Outcome Breakdown
Outcome Unknown
1,238 (31.4%)
Recovered/Normal
1,207 (30.6%)
Ongoing
1,119 (28.4%)
Died
166 (4.2%)
Recovered with Sequela
121 (3.1%)
Euthanized
89 (2.3%)
Gender Distribution
Male 2,138 (50.6%)
Female 1,940 (45.9%)
Unknown 128 (3.0%)
Mixed 21 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 176 | |
| 2011 | 188 | |
| 2012 | 253 | |
| 2013 | 273 | |
| 2014 | 260 | |
| 2015 | 247 | |
| 2016 | 298 | |
| 2017 | 288 | |
| 2018 | 299 | |
| 2019 | 354 | |
| 2020 | 301 | |
| 2021 | 248 | |
| 2022 | 294 | |
| 2023 | 283 | |
| 2024 | 287 | |
| 2025 | 178 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #47 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.