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Breed profile · FDA CVM July 2026 extract

Deutsche Dogge, Great Dane adverse-event record

Adverse-event filings for Deutsche Dogge, Great Dane (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#46 of 510
by report volume (all breeds)
4,353
FDA CVM reports on file
6.0%
death-coded share of reports
#104 of 275
by death-coded share (≥50 reports)

How the 4,353 reports break down

By recorded gender -- every report on file for Deutsche Dogge, Great Dane, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 354 265.5 177 88.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Deutsche Dogge, Great Dane drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Deutsche Dogge, Great Dane ranks #46 of 510 by total reports (4,353) and #104 of 275 by death-coded share (6.0%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#46
This breed, reports of 510
#104
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Deutsche Dogge, Great Dane has 4,353 reports now versus 4,297 in that prior snapshot: 56 more (1.3%).

Report change
+56
Death-coded reports
+3
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Deutsche Dogge, Great Dane changes

Total Reports

4,353

Highest-reported breed

Deaths Reported

260

of 4,353 reports

Death-coded share of reports

6.0%

Above-median death-coded share

Avg Age at Report

3.5 yr

49.8 kg avg weight

Breed Safety Scorecard

D (45/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
6.0%

Share of reports coded as a fatality

Euthanasia rate C-
2.1%

Share of reports resulting in euthanasia

Full recovery rate D
28.0%

Share of reports coded "Recovered/Normal"

5-year trend C
+3%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Deutsche Dogge, Great Dane death-coded reports 6.0%
Cross-breed median

6.0% of 4,353 deutsche dogge, great dane reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Deutsche Dogge, Great Dane's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

6% 62nd percentile Higher share than 62% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Deutsche Dogge, Great Dane 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Deutsche Dogge, Great Dane among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Deutsche Dogge, Great Dane vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 49.8 kg (109.8 lbs)

Top Reported Reactions

Vomiting 825
Diarrhoea 434
Emesis 349
Lack of efficacy (endoparasite) - heartworm 335
Lethargy (see also Central nervous system depression in 'Neurological') 293
Lack of efficacy - NOS 247
INEFFECTIVE, HEARTWORM LARVAE 237
Lack of efficacy (endoparasite) - hookworm 229
Lack of efficacy (ectoparasite) - flea 162
Anorexia 144
Underdose 142
Death 139
Seizure NOS 134
Weight loss 129
Other abnormal test result NOS 119

Most Referenced Drugs

Milbemycin Oxime + Spinosad 965
Ivermectin + Pyrantel As Pamoate Salt 646
Moxidectin 371
Pyrantel Pamoate;Sarolaner 304
Milbemycin Oxime + Praziquantel 298
Afoxolaner 241
Carprofen 203
Spinosad 200
Fluralaner Chew Tablets 199
Bedinvetmab 151
Fluralaner 13.64% 12-Week Chew 141
Sarolaner 108
Oclacitinib Maleate 107
Melarsomine Dihydrochloride 78
Gabapentin 76

Outcome Breakdown

Outcome Unknown
1,263 (31.1%)
Recovered/Normal
1,221 (30.0%)
Ongoing
1,201 (29.5%)
Died
167 (4.1%)
Recovered with Sequela
121 (3.0%)
Euthanized
93 (2.3%)

Gender Distribution

Male 2,204 (50.6%)
Female 1,995 (45.8%)
Unknown 133 (3.1%)
Mixed 21 (0.5%)

Reports by Year

Year Reports Trend
2010 176
2011 188
2012 253
2013 273
2014 260
2015 247
2016 298
2017 288
2018 299
2019 354
2020 301
2021 248
2022 294
2023 285
2024 287
2025 256
2026 46

Deutsche Dogge, Great Dane: high-volume FDA adverse-event cohort

Signature read: 4,353 reports place Deutsche Dogge, Great Dane in the upper third of breed filing volume (#46 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Deutsche Dogge, Great Dane sits at #46 of 510 by report volume among all breeds and #40 of 298 among dog breeds, with 4,353 reports and 260 (6.0%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #104 of 275. Mean age at report: 3.5 years, average weight 49.8 kg (109.8 lbs).

Top reported signs: Vomiting (825), Diarrhoea (434), Emesis (349). Most-referenced drug: Milbemycin Oxime + Spinosad (965 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (646) and Moxidectin (371).

Outcome coding on 4,066 status-recorded reports is dominated by Outcome Unknown (31.1%). Annual submissions ranged 46-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Terrier - West Highland White
4,343 reports · 4.9% death-coded
Dachshund - Miniature
4,234 reports · 4.6% death-coded
Great Pyrenees
4,513 reports · 3.8% death-coded
Poodle - Toy
4,180 reports · 4.0% death-coded
Sheepdog - Shetland
4,159 reports · 6.7% death-coded
Doberman Pinscher
4,631 reports · 5.7% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Deutsche Dogge, Great Dane drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (6.0% death-coded here).

Norwegian Forest 5.7% · Cat Crossbred Feline/cat 6.3% · Cat Egyptian Mau 5.3% · Cat Domestic Longhair 7.0% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (49.8 kg here).

Mixed (Pig) 49.2 kg · Pig Duroc 50.4 kg · Pig Mixed (Goat) 48.5 kg · Goat Crossbred Porcine/Pig 51.1 kg · Pig

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Deutsche Dogge, Great Dane? ▼
There are 4,353 adverse event reports involving Deutsche Dogge, Great Dane in the FDA database, of which 260 were death-coded (6.0% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Deutsche Dogge, Great Dane ranks #46 of 510 by report volume among all breeds PlainBreed indexes (#40 of 298 among dog breeds).
Where does Deutsche Dogge, Great Dane sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Deutsche Dogge, Great Dane is #46 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #40 of 298. Among breeds with at least 50 reports, its death-coded share ranks #104 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Deutsche Dogge, Great Dane? ▼
The most commonly reported adverse reactions for Deutsche Dogge, Great Dane are Vomiting (825 reports), Diarrhoea (434 reports), Emesis (349 reports), Lack of efficacy (endoparasite) - heartworm (335 reports), Lethargy (see also Central nervous system depression in 'Neurological') (293 reports).
What drugs are most frequently associated with Deutsche Dogge, Great Dane adverse events? ▼
The drugs most frequently referenced in Deutsche Dogge, Great Dane adverse event reports are Milbemycin Oxime + Spinosad (965 reports), Ivermectin + Pyrantel As Pamoate Salt (646 reports), Moxidectin (371 reports), Pyrantel Pamoate;Sarolaner (304 reports), Milbemycin Oxime + Praziquantel (298 reports).
What is the average age of Deutsche Dogge, Great Dane in adverse event reports? ▼
The average age of Deutsche Dogge, Great Dane at the time of adverse event reports is 3.5 years, with an average weight of 49.8 kg (109.8 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Deutsche Dogge, Great Dane (Dog), extract as of July 2026 extract. 4,353 reports · 260 death-coded (6.0% of reports, not a mortality rate) · #46 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →