Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,617
Total Reports
52
Deaths Reported
320.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 16.8 kg (37.0 lbs)
Top Reported Reactions
Vomiting 443
Lethargy (see also Central nervous system depression in 'Neurological') 160
Diarrhoea 139
Emesis 138
Lack of efficacy (endoparasite) - hookworm 92
Lack of efficacy - NOS 83
Anorexia 67
Lack of efficacy (ectoparasite) - flea 65
Seizure NOS 52
Digestive tract disorder NOS 51
Emesis (multiple) 49
Not eating 43
Other abnormal test result NOS 42
Lack of efficacy (ectoparasite) - tick NOS 39
Panting 37
Most Referenced Drugs
Milbemycin Oxime + Spinosad 235
Ivermectin + Pyrantel As Pamoate Salt 186
Afoxolaner 159
Oclacitinib Maleate 119
Pyrantel Pamoate;Sarolaner 108
Fluralaner Chew Tablets 106
Spinosad 75
Carprofen 58
Fluralaner 13.64% 12-Week Chew 52
Moxidectin 46
Milbemycin Oxime + Praziquantel 42
Sarolaner 40
Bedinvetmab 36
Maropitant Citrate 25
Prednisone 24
Outcome Breakdown
Recovered/Normal
613 (40.4%)
Outcome Unknown
409 (26.9%)
Ongoing
408 (26.9%)
Recovered with Sequela
37 (2.4%)
Euthanized
28 (1.8%)
Died
24 (1.6%)
Gender Distribution
Male 832 (51.5%)
Female 757 (46.8%)
Unknown 25 (1.5%)
Mixed 3 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 48 | |
| 2011 | 66 | |
| 2012 | 101 | |
| 2013 | 96 | |
| 2014 | 119 | |
| 2015 | 135 | |
| 2016 | 155 | |
| 2017 | 143 | |
| 2018 | 131 | |
| 2019 | 122 | |
| 2020 | 87 | |
| 2021 | 95 | |
| 2022 | 95 | |
| 2023 | 81 | |
| 2024 | 85 | |
| 2025 | 58 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #85 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.