Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
952
Total Reports
48
Deaths Reported
500.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 21.1 kg (46.5 lbs)
Top Reported Reactions
Vomiting 164
INEFFECTIVE, HEARTWORM LARVAE 62
Lack of efficacy - NOS 61
Lack of efficacy (ectoparasite) - flea 60
Emesis 59
Diarrhoea 57
Lack of efficacy (endoparasite) - hookworm 57
Lethargy (see also Central nervous system depression in 'Neurological') 55
Anorexia 48
Depression 43
Seizure NOS 38
Ataxia 36
Lack of efficacy (endoparasite) - heartworm 32
INEFFECTIVE, ASCARIDS NOS 31
Death by euthanasia 30
Most Referenced Drugs
Milbemycin Oxime + Spinosad 199
Spinosad 76
Milbemycin Oxime + Praziquantel 76
Pyrantel Pamoate;Sarolaner 70
Ivermectin, Pyrantel 50
Oclacitinib Maleate 49
Carprofen 48
Moxidectin 43
Milbemycin 40
Sarolaner 35
Bedinvetmab 29
Cyclosporine 23
Lotilaner 22
Selamectin 21
Ivermectin + Pyrantel As Pamoate Salt 16
Outcome Breakdown
Recovered/Normal
216 (31.7%)
Outcome Unknown
205 (30.1%)
Ongoing
196 (28.7%)
Died
27 (4.0%)
Euthanized
21 (3.1%)
Recovered with Sequela
17 (2.5%)
Gender Distribution
Female 499 (52.4%)
Male 441 (46.3%)
Unknown 11 (1.2%)
Mixed 1 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 137 | |
| 2011 | 117 | |
| 2012 | 63 | |
| 2013 | 62 | |
| 2014 | 56 | |
| 2015 | 50 | |
| 2016 | 66 | |
| 2017 | 39 | |
| 2018 | 32 | |
| 2019 | 43 | |
| 2020 | 45 | |
| 2021 | 36 | |
| 2022 | 54 | |
| 2023 | 49 | |
| 2024 | 57 | |
| 2025 | 46 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #112 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.