Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
121
Total Reports
2
Deaths Reported
170.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 23.1 kg (50.9 lbs)
Top Reported Reactions
Vomiting 22
Lethargy (see also Central nervous system depression in 'Neurological') 10
Lack of efficacy (endoparasite) - hookworm 9
Diarrhoea 9
Lack of efficacy (ectoparasite) - tick NOS 9
Lack of efficacy (endoparasite) - heartworm 8
INEFFECTIVE, HEARTWORM LARVAE 7
Digestive tract disorder NOS 7
Emesis 6
Seizure NOS 6
Lack of efficacy (bacteria) - Borrelia 6
INEFFECTIVE, ASCARIDS NOS 5
Lack of efficacy (endoparasite) - whipworm 5
Lack of efficacy (bacteria) - NOS 5
Depression 4
Most Referenced Drugs
Afoxolaner 35
Ivermectin + Pyrantel As Pamoate Salt 26
Milbemycin Oxime + Spinosad 12
Ivermectin, Pyrantel 6
Recombitek Lyme - 2126.R0 6
Milbemycin Oxime + Praziquantel 5
Fluralaner 13.64% 12-Week Chew 5
Spinosad 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Grapiprant 3
Milbemycin/Lufenuron/Pzq Chew 3
Dexmedetomidine Hydrochloride 2
Maropitant 2
Carprofen 2
Milbemycin, Lufenuron 2
Outcome Breakdown
Outcome Unknown
54 (55.1%)
Recovered/Normal
21 (21.4%)
Ongoing
19 (19.4%)
Recovered with Sequela
2 (2.0%)
Euthanized
1 (1.0%)
Died
1 (1.0%)
Gender Distribution
Male 60 (49.6%)
Female 60 (49.6%)
Unknown 1 (0.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 16 | |
| 2011 | 7 | |
| 2012 | 5 | |
| 2013 | 9 | |
| 2014 | 7 | |
| 2015 | 11 | |
| 2016 | 5 | |
| 2017 | 8 | |
| 2018 | 6 | |
| 2019 | 9 | |
| 2020 | 4 | |
| 2021 | 8 | |
| 2022 | 9 | |
| 2023 | 8 | |
| 2024 | 9 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #222 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.