Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
735
Total Reports
39
Deaths Reported
530.0%
Death Rate
7.1 yr
Avg Age at Report
Average weight at time of report: 5.6 kg (12.3 lbs)
Top Reported Reactions
Vomiting 196
Lethargy (see also Central nervous system depression in 'Neurological') 93
Emesis 80
Diarrhoea 73
Lack of efficacy (ectoparasite) - flea 53
Lack of efficacy - NOS 42
Anorexia 34
Seizure NOS 32
Emesis (multiple) 30
Lack of efficacy (endoparasite) - hookworm 27
Behavioural disorder NOS 26
Death by euthanasia 26
Shaking 25
Trembling 21
Elevated serum alkaline phosphatase (SAP) 21
Most Referenced Drugs
Milbemycin Oxime + Spinosad 165
Spinosad 92
Ivermectin + Pyrantel As Pamoate Salt 52
Afoxolaner 47
Fluralaner Chew Tablets 38
Trilostane 36
Moxidectin 24
Sarolaner 24
Oclacitinib Maleate 23
Milbemycin Oxime + Praziquantel 21
Pyrantel Pamoate;Sarolaner 20
Imidacloprid + Moxidectin 15
Maropitant Citrate 14
Selamectin 13
Carprofen 11
Outcome Breakdown
Recovered/Normal
276 (41.6%)
Outcome Unknown
206 (31.1%)
Ongoing
115 (17.3%)
Recovered with Sequela
27 (4.1%)
Euthanized
27 (4.1%)
Died
12 (1.8%)
Gender Distribution
Male 372 (50.6%)
Female 347 (47.2%)
Unknown 13 (1.8%)
Mixed 3 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 35 | |
| 2011 | 54 | |
| 2012 | 74 | |
| 2013 | 74 | |
| 2014 | 54 | |
| 2015 | 67 | |
| 2016 | 70 | |
| 2017 | 59 | |
| 2018 | 40 | |
| 2019 | 50 | |
| 2020 | 38 | |
| 2021 | 25 | |
| 2022 | 25 | |
| 2023 | 26 | |
| 2024 | 30 | |
| 2025 | 14 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #119 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.