Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
42
Total Reports
3
Deaths Reported
710.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 5.0 kg (11.0 lbs)
Top Reported Reactions
Vomiting 12
Seizure NOS 5
Emesis (multiple) 4
Emesis 3
Behavioural disorder NOS 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Lack of efficacy (ectoparasite) - flea 3
Tachycardia 2
Other abnormal test result NOS 2
Death 2
Lack of efficacy - NOS 2
Pica NOS 2
Aggression 2
Shaking 2
Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders') 1
Most Referenced Drugs
Milbemycin Oxime + Spinosad 8
Afoxolaner 7
Pyrantel Pamoate;Sarolaner 7
Milbemycin Oxime + Praziquantel 6
Trilostane 6
Ivermectin + Pyrantel As Pamoate Salt 3
Deracoxib 2
Miconazole + Polymyxin B + Prednisolone 2
Pimobendan 2
Minocycline 1
Niacinamide 1
Fipronil 1
Anesthetic (Unknown) 1
Milbemycin Oxime, Lufenuron 1
Milbemycin Oxime 1
Outcome Breakdown
Recovered/Normal
19 (45.2%)
Outcome Unknown
12 (28.6%)
Ongoing
7 (16.7%)
Died
2 (4.8%)
Recovered with Sequela
1 (2.4%)
Euthanized
1 (2.4%)
Gender Distribution
Male 29 (69.0%)
Female 12 (28.6%)
Mixed 1 (2.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 2 | |
| 2013 | 1 | |
| 2014 | 3 | |
| 2015 | 1 | |
| 2016 | 4 | |
| 2017 | 5 | |
| 2018 | 1 | |
| 2019 | 4 | |
| 2020 | 3 | |
| 2021 | 5 | |
| 2022 | 4 | |
| 2023 | 4 | |
| 2024 | 1 | |
| 2025 | 4 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #285 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.