Total Reports
5,775
FDA CVM filings
Dog /
FDA CVM · 2025 release 5,775 reports on file
Spaniel - King Charles Cavalier - FDA Adverse Event Profile
Adverse-event records for Spaniel - King Charles Cavalier (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Spaniel - King Charles Cavalier's FDA record: #37 most-reported dog breed, 5,775 total reports, 4.3% death-coded (248 reports).
- #37
- most-reported dog breed
- 4.3%
- death-coded report share
- 1,305
- Vomiting - top reaction
- 4.9 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
248
of 5,775 reports
Death Rate
4.3%
death-coded share
Avg Age at Report
4.9 yr
8.8 kg avg weight
Death-Coded Outcome Share
Spaniel - King Charles Cavalier death-coded reports 4.3%
Cross-breed median
4.3% of 5,775 spaniel - king charles cavalier reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 8.8 kg (19.4 lbs)
Top Reported Reactions
Vomiting 1,305
Diarrhoea 600
Lethargy (see also Central nervous system depression in 'Neurological') 533
Emesis 388
Lack of efficacy (endoparasite) - hookworm 356
Lack of efficacy (ectoparasite) - flea 337
Seizure NOS 263
Lack of efficacy - NOS 208
Digestive tract disorder NOS 166
Behavioural disorder NOS 154
Anorexia 150
Emesis (multiple) 146
Lack of efficacy (bacteria) - Borrelia 144
Not eating 137
Lethargy (see also Central nervous system depression in Neurological) 136
Most Referenced Drugs
Milbemycin Oxime + Spinosad 894
Pyrantel Pamoate;Sarolaner 696
Afoxolaner 469
Ivermectin + Pyrantel As Pamoate Salt 458
Pimobendan 389
Spinosad 312
Milbemycin Oxime + Praziquantel 249
Moxidectin 238
Sarolaner 198
Fluralaner Chew Tablets 186
Fluralaner 13.64% 12-Week Chew 180
Oclacitinib Maleate 178
Lotilaner 139
Carprofen 121
Selamectin 112
Outcome Breakdown
Recovered/Normal
2,064 (38.0%)
Outcome Unknown
1,598 (29.4%)
Ongoing
1,417 (26.1%)
Died
149 (2.7%)
Recovered with Sequela
105 (1.9%)
Euthanized
99 (1.8%)
Gender Distribution
Male 2,957 (51.2%)
Female 2,685 (46.5%)
Unknown 109 (1.9%)
Mixed 24 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 168 | |
| 2011 | 221 | |
| 2012 | 327 | |
| 2013 | 350 | |
| 2014 | 328 | |
| 2015 | 354 | |
| 2016 | 341 | |
| 2017 | 377 | |
| 2018 | 343 | |
| 2019 | 336 | |
| 2020 | 368 | |
| 2021 | 379 | |
| 2022 | 441 | |
| 2023 | 532 | |
| 2024 | 541 | |
| 2025 | 369 | |
Spaniel - King Charles Cavalier Pet Health Insights
Spaniel - King Charles Cavalier accounts for 5,775 FDA adverse event reports, ranking #37 by volume among dog breeds, with 248 reports (4.3%) coded as a death outcome. Mean age at report: 4.9 years, average weight 8.8 kg (19.4 lbs).
Top reported signs: Vomiting (1,305), Diarrhoea (600), Lethargy (see also Central nervous system depression in 'Neurological') (533). Most-referenced drug: Milbemycin Oxime + Spinosad (894 reports), followed by Pyrantel Pamoate;Sarolaner (696) and Afoxolaner (469).
Outcome coding on 5,432 status-recorded reports is dominated by Recovered/Normal (38.0%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Spaniel - King Charles Cavalier? ▼
There are 5,775 adverse event reports involving Spaniel - King Charles Cavalier in the FDA database, with 248 reports involving death (4.3% death rate). Spaniel - King Charles Cavalier ranks #37 by report volume.
What are the most common adverse reactions reported for Spaniel - King Charles Cavalier? ▼
The most commonly reported adverse reactions for Spaniel - King Charles Cavalier are Vomiting (1,305 reports), Diarrhoea (600 reports), Lethargy (see also Central nervous system depression in 'Neurological') (533 reports), Emesis (388 reports), Lack of efficacy (endoparasite) - hookworm (356 reports).
What drugs are most frequently associated with Spaniel - King Charles Cavalier adverse events? ▼
The drugs most frequently referenced in Spaniel - King Charles Cavalier adverse event reports are Milbemycin Oxime + Spinosad (894 reports), Pyrantel Pamoate;Sarolaner (696 reports), Afoxolaner (469 reports), Ivermectin + Pyrantel As Pamoate Salt (458 reports), Pimobendan (389 reports).
What is the average age of Spaniel - King Charles Cavalier in adverse event reports? ▼
The average age of Spaniel - King Charles Cavalier at the time of adverse event reports is 4.9 years, with an average weight of 8.8 kg (19.4 lbs).
Does a high number of adverse event reports mean Spaniel - King Charles Cavalier is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Spaniel - King Charles Cavalier safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.