Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
5,775
Total Reports
248
Deaths Reported
430.0%
Death Rate
4.9 yr
Avg Age at Report
Average weight at time of report: 8.8 kg (19.4 lbs)
Top Reported Reactions
Vomiting 1,305
Diarrhoea 600
Lethargy (see also Central nervous system depression in 'Neurological') 533
Emesis 388
Lack of efficacy (endoparasite) - hookworm 356
Lack of efficacy (ectoparasite) - flea 337
Seizure NOS 263
Lack of efficacy - NOS 208
Digestive tract disorder NOS 166
Behavioural disorder NOS 154
Anorexia 150
Emesis (multiple) 146
Lack of efficacy (bacteria) - Borrelia 144
Not eating 137
Lethargy (see also Central nervous system depression in Neurological) 136
Most Referenced Drugs
Milbemycin Oxime + Spinosad 894
Pyrantel Pamoate;Sarolaner 696
Afoxolaner 469
Ivermectin + Pyrantel As Pamoate Salt 458
Pimobendan 389
Spinosad 312
Milbemycin Oxime + Praziquantel 249
Moxidectin 238
Sarolaner 198
Fluralaner Chew Tablets 186
Fluralaner 13.64% 12-Week Chew 180
Oclacitinib Maleate 178
Lotilaner 139
Carprofen 121
Selamectin 112
Outcome Breakdown
Recovered/Normal
2,064 (38.0%)
Outcome Unknown
1,598 (29.4%)
Ongoing
1,417 (26.1%)
Died
149 (2.7%)
Recovered with Sequela
105 (1.9%)
Euthanized
99 (1.8%)
Gender Distribution
Male 2,957 (51.2%)
Female 2,685 (46.5%)
Unknown 109 (1.9%)
Mixed 24 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 168 | |
| 2011 | 221 | |
| 2012 | 327 | |
| 2013 | 350 | |
| 2014 | 328 | |
| 2015 | 354 | |
| 2016 | 341 | |
| 2017 | 377 | |
| 2018 | 343 | |
| 2019 | 336 | |
| 2020 | 368 | |
| 2021 | 379 | |
| 2022 | 441 | |
| 2023 | 532 | |
| 2024 | 541 | |
| 2025 | 369 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #37 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.