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Breed profile · FDA CVM July 2026 extract

Spaniel - King Charles Cavalier adverse-event record

Adverse-event filings for Spaniel - King Charles Cavalier (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#36 of 510
by report volume (all breeds)
6,052
FDA CVM reports on file
4.2%
death-coded share of reports
#168 of 275
by death-coded share (≥50 reports)

How the 6,052 reports break down

By recorded gender -- every report on file for Spaniel - King Charles Cavalier, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 551 413.25 275.5 137.75 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Spaniel - King Charles Cavalier drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Spaniel - King Charles Cavalier ranks #36 of 510 by total reports (6,052) and #168 of 275 by death-coded share (4.2%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#36
This breed, reports of 510
#168
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Spaniel - King Charles Cavalier has 6,052 reports now versus 5,943 in that prior snapshot: 109 more (1.8%).

Report change
+109
Death-coded reports
+6
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Spaniel - King Charles Cavalier changes

Total Reports

6,052

Highest-reported breed

Deaths Reported

257

of 6,052 reports

Death-coded share of reports

4.2%

Below-median death-coded share

Avg Age at Report

4.8 yr

8.8 kg avg weight

Breed Safety Scorecard

C (58/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate C
4.2%

Share of reports coded as a fatality

Euthanasia rate B
1.7%

Share of reports resulting in euthanasia

Full recovery rate B+
35.3%

Share of reports coded "Recovered/Normal"

5-year trend F
+45%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Spaniel - King Charles Cavalier death-coded reports 4.2%
Cross-breed median

4.2% of 6,052 spaniel - king charles cavalier reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Spaniel - King Charles Cavalier's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

4% 39th percentile Higher share than 39% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Spaniel - King Charles Cavalier 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Spaniel - King Charles Cavalier among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Spaniel - King Charles Cavalier vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 8.8 kg (19.4 lbs)

Top Reported Reactions

Vomiting 1,352
Diarrhoea 630
Lethargy (see also Central nervous system depression in 'Neurological') 533
Emesis 390
Lack of efficacy (endoparasite) - hookworm 379
Lack of efficacy (ectoparasite) - flea 359
Seizure NOS 284
Lack of efficacy - NOS 220
Digestive tract disorder NOS 166
Lack of efficacy (bacteria) - Borrelia 164
Lethargy (see also Central nervous system depression in Neurological) 164
Behavioural disorder NOS 160
Emesis (multiple) 159
Anorexia 155
Lack of efficacy (endoparasite) - roundworm NOS 151

Most Referenced Drugs

Milbemycin Oxime + Spinosad 897
Pyrantel Pamoate;Sarolaner 768
Afoxolaner 483
Ivermectin + Pyrantel As Pamoate Salt 472
Pimobendan 394
Spinosad 312
Milbemycin Oxime + Praziquantel 262
Moxidectin 253
Fluralaner 13.64% 12-Week Chew 201
Sarolaner 200
Oclacitinib Maleate 190
Fluralaner Chew Tablets 186
Lotilaner 150
Carprofen 127
Selamectin 113

Outcome Breakdown

Recovered/Normal
2,138 (37.4%)
Outcome Unknown
1,688 (29.6%)
Ongoing
1,520 (26.6%)
Died
153 (2.7%)
Recovered with Sequela
106 (1.9%)
Euthanized
104 (1.8%)

Gender Distribution

Male 3,110 (51.4%)
Female 2,803 (46.3%)
Unknown 115 (1.9%)
Mixed 24 (0.4%)

Reports by Year

Year Reports Trend
2010 168
2011 221
2012 327
2013 350
2014 328
2015 354
2016 341
2017 377
2018 343
2019 336
2020 368
2021 379
2022 442
2023 533
2024 544
2025 551
2026 90

Spaniel - King Charles Cavalier: high-volume FDA adverse-event cohort

Signature read: 6,052 reports place Spaniel - King Charles Cavalier in the upper third of breed filing volume (#36 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Spaniel - King Charles Cavalier sits at #36 of 510 by report volume among all breeds and #31 of 298 among dog breeds, with 6,052 reports and 257 (4.2%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #168 of 275. Mean age at report: 4.8 years, average weight 8.8 kg (19.4 lbs).

Top reported signs: Vomiting (1,352), Diarrhoea (630), Lethargy (see also Central nervous system depression in 'Neurological') (533). Most-referenced drug: Milbemycin Oxime + Spinosad (897 reports), followed by Pyrantel Pamoate;Sarolaner (768) and Afoxolaner (483).

Outcome coding on 5,709 status-recorded reports is dominated by Recovered/Normal (37.4%). Annual submissions ranged 90-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Dog (other)
5,922 reports · 4.3% death-coded
Rottweiler
6,557 reports · 8.2% death-coded
Poodle - Miniature
5,483 reports · 3.6% death-coded
Schnauzer (unspecified)
5,387 reports · 4.1% death-coded
Mixed (Dog)
5,355 reports · 5.7% death-coded
Bichon Frise
7,085 reports · 3.9% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Spaniel - King Charles Cavalier drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (4.2% death-coded here).

Siberian 4.2% · Cat Bengal 4.6% · Cat British cat 3.8% · Cat Scottish Fold Longhair 4.8% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (8.8 kg here).

Primate (other) 10.1 kg · Primate Nigerian Dwarf 7.5 kg · Goat Maine Coon 6.1 kg · Cat Monkey (unspecified) 11.6 kg · Monkey

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Spaniel - King Charles Cavalier? ▼
There are 6,052 adverse event reports involving Spaniel - King Charles Cavalier in the FDA database, of which 257 were death-coded (4.2% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Spaniel - King Charles Cavalier ranks #36 of 510 by report volume among all breeds PlainBreed indexes (#31 of 298 among dog breeds).
Where does Spaniel - King Charles Cavalier sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Spaniel - King Charles Cavalier is #36 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #31 of 298. Among breeds with at least 50 reports, its death-coded share ranks #168 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Spaniel - King Charles Cavalier? ▼
The most commonly reported adverse reactions for Spaniel - King Charles Cavalier are Vomiting (1,352 reports), Diarrhoea (630 reports), Lethargy (see also Central nervous system depression in 'Neurological') (533 reports), Emesis (390 reports), Lack of efficacy (endoparasite) - hookworm (379 reports).
What drugs are most frequently associated with Spaniel - King Charles Cavalier adverse events? ▼
The drugs most frequently referenced in Spaniel - King Charles Cavalier adverse event reports are Milbemycin Oxime + Spinosad (897 reports), Pyrantel Pamoate;Sarolaner (768 reports), Afoxolaner (483 reports), Ivermectin + Pyrantel As Pamoate Salt (472 reports), Pimobendan (394 reports).
What is the average age of Spaniel - King Charles Cavalier in adverse event reports? ▼
The average age of Spaniel - King Charles Cavalier at the time of adverse event reports is 4.8 years, with an average weight of 8.8 kg (19.4 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Spaniel - King Charles Cavalier (Dog), extract as of July 2026 extract. 6,052 reports · 257 death-coded (4.2% of reports, not a mortality rate) · #36 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →