Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,291
Total Reports
67
Deaths Reported
520.0%
Death Rate
5.1 yr
Avg Age at Report
Average weight at time of report: 35.7 kg (78.7 lbs)
Top Reported Reactions
Vomiting 218
Lethargy (see also Central nervous system depression in 'Neurological') 115
Diarrhoea 109
Lack of efficacy (endoparasite) - heartworm 97
Emesis 96
Lack of efficacy - NOS 95
INEFFECTIVE, HEARTWORM LARVAE 68
Lack of efficacy (endoparasite) - hookworm 66
Anorexia 55
Digestive tract disorder NOS 46
Lack of efficacy (ectoparasite) - flea 42
Death 38
Seizure NOS 38
Emesis (multiple) 38
Ataxia 33
Most Referenced Drugs
Milbemycin Oxime + Spinosad 277
Ivermectin + Pyrantel As Pamoate Salt 142
Pyrantel Pamoate;Sarolaner 88
Afoxolaner 78
Moxidectin 64
Spinosad 63
Milbemycin Oxime + Praziquantel 54
Oclacitinib Maleate 51
Carprofen 46
Fluralaner Chew Tablets 41
Bedinvetmab 37
Fluralaner 13.64% 12-Week Chew 25
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 23
Sarolaner 21
Milbemycin 18
Outcome Breakdown
Outcome Unknown
388 (32.3%)
Recovered/Normal
377 (31.4%)
Ongoing
322 (26.8%)
Recovered with Sequela
47 (3.9%)
Died
40 (3.3%)
Euthanized
27 (2.2%)
Gender Distribution
Male 668 (51.7%)
Female 603 (46.7%)
Unknown 15 (1.2%)
Mixed 5 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 54 | |
| 2011 | 60 | |
| 2012 | 105 | |
| 2013 | 82 | |
| 2014 | 83 | |
| 2015 | 88 | |
| 2016 | 79 | |
| 2017 | 90 | |
| 2018 | 86 | |
| 2019 | 75 | |
| 2020 | 87 | |
| 2021 | 87 | |
| 2022 | 67 | |
| 2023 | 86 | |
| 2024 | 89 | |
| 2025 | 73 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #94 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.