Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
159
Total Reports
8
Deaths Reported
500.0%
Death Rate
6.8 yr
Avg Age at Report
Average weight at time of report: 8.7 kg (19.2 lbs)
Top Reported Reactions
Vomiting 36
Lethargy (see also Central nervous system depression in 'Neurological') 23
Diarrhoea 16
Emesis 14
Lack of efficacy (endoparasite) - hookworm 10
INEFFECTIVE, HEARTWORM LARVAE 8
Digestive tract disorder NOS 7
Emesis (multiple) 7
Lack of efficacy (endoparasite) - heartworm 7
Lack of efficacy - NOS 6
Not eating 6
Seizure NOS 6
Death by euthanasia 5
Elevated serum alkaline phosphatase (SAP) 5
Pruritus 5
Most Referenced Drugs
Milbemycin Oxime + Spinosad 35
Ivermectin + Pyrantel As Pamoate Salt 20
Afoxolaner 12
Spinosad 9
Moxidectin 8
Trilostane 6
Fluralaner Chew Tablets 5
Pyrantel Pamoate;Sarolaner 5
Selamectin 4
Ivermectin 4
Fenbendazol Granules 4
Sarolaner 4
Fluralaner 13.64% 12-Week Chew 4
Imidacloprid + Moxidectin 3
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 3
Outcome Breakdown
Recovered/Normal
47 (32.2%)
Outcome Unknown
47 (32.2%)
Ongoing
35 (24.0%)
Recovered with Sequela
9 (6.2%)
Died
4 (2.7%)
Euthanized
4 (2.7%)
Gender Distribution
Female 83 (52.2%)
Male 73 (45.9%)
Unknown 3 (1.9%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 6 | |
| 2011 | 11 | |
| 2012 | 14 | |
| 2013 | 13 | |
| 2014 | 7 | |
| 2015 | 16 | |
| 2016 | 12 | |
| 2017 | 19 | |
| 2018 | 5 | |
| 2019 | 15 | |
| 2020 | 9 | |
| 2021 | 9 | |
| 2022 | 7 | |
| 2023 | 4 | |
| 2024 | 9 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #197 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.