Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
837
Total Reports
40
Deaths Reported
480.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 38.2 kg (84.2 lbs)
Top Reported Reactions
Vomiting 149
Lethargy (see also Central nervous system depression in 'Neurological') 99
Diarrhoea 81
Lack of efficacy - NOS 53
Emesis 52
Lack of efficacy (endoparasite) - heartworm 49
Lack of efficacy (endoparasite) - hookworm 45
INEFFECTIVE, HEARTWORM LARVAE 41
Anorexia 38
Lack of efficacy (ectoparasite) - flea 30
Seizure NOS 29
Other abnormal test result NOS 26
Underdose 26
Lack of efficacy (ectoparasite) - tick NOS 25
Ataxia 25
Most Referenced Drugs
Milbemycin Oxime + Spinosad 149
Ivermectin + Pyrantel As Pamoate Salt 96
Pyrantel Pamoate;Sarolaner 63
Afoxolaner 61
Milbemycin Oxime + Praziquantel 44
Bedinvetmab 44
Spinosad 32
Fluralaner Chew Tablets 31
Moxidectin 28
Carprofen 27
Fluralaner 13.64% 12-Week Chew 21
Trilostane 17
Oclacitinib Maleate 17
Grapiprant 17
Gabapentin 15
Outcome Breakdown
Outcome Unknown
263 (33.5%)
Recovered/Normal
234 (29.8%)
Ongoing
211 (26.9%)
Recovered with Sequela
36 (4.6%)
Died
24 (3.1%)
Euthanized
16 (2.0%)
Gender Distribution
Male 437 (52.2%)
Female 385 (46.0%)
Unknown 11 (1.3%)
Mixed 4 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 23 | |
| 2011 | 33 | |
| 2012 | 57 | |
| 2013 | 59 | |
| 2014 | 49 | |
| 2015 | 67 | |
| 2016 | 61 | |
| 2017 | 67 | |
| 2018 | 57 | |
| 2019 | 64 | |
| 2020 | 54 | |
| 2021 | 46 | |
| 2022 | 46 | |
| 2023 | 53 | |
| 2024 | 55 | |
| 2025 | 46 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #116 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.