Total Reports
837
FDA CVM filings
Dog /
FDA CVM · 2025 release 837 reports on file
Alaskan Malamute - FDA Adverse Event Profile
Adverse-event records for Alaskan Malamute (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Alaskan Malamute is #116 by FDA report volume; 4.8% of its 837 reports (40) were death-coded.
- #116
- most-reported dog breed
- 4.8%
- death-coded report share
- 149
- Vomiting - top reaction
- 5.4 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
40
of 837 reports
Death Rate
4.8%
death-coded share
Avg Age at Report
5.4 yr
38.2 kg avg weight
Death-Coded Outcome Share
Alaskan Malamute death-coded reports 4.8%
Cross-breed median
4.8% of 837 alaskan malamute reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 38.2 kg (84.2 lbs)
Top Reported Reactions
Vomiting 149
Lethargy (see also Central nervous system depression in 'Neurological') 99
Diarrhoea 81
Lack of efficacy - NOS 53
Emesis 52
Lack of efficacy (endoparasite) - heartworm 49
Lack of efficacy (endoparasite) - hookworm 45
INEFFECTIVE, HEARTWORM LARVAE 41
Most Referenced Drugs
Milbemycin Oxime + Spinosad 149
Ivermectin + Pyrantel As Pamoate Salt 96
Pyrantel Pamoate;Sarolaner 63
Afoxolaner 61
Milbemycin Oxime + Praziquantel 44
Bedinvetmab 44
Spinosad 32
Fluralaner Chew Tablets 31
Outcome Breakdown
Outcome Unknown
263 (33.5%)
Recovered/Normal
234 (29.8%)
Ongoing
211 (26.9%)
Recovered with Sequela
36 (4.6%)
Died
24 (3.1%)
Euthanized
16 (2.0%)
Gender Distribution
Male 437 (52.2%)
Female 385 (46.0%)
Unknown 11 (1.3%)
Mixed 4 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 23 | |
| 2011 | 33 | |
| 2012 | 57 | |
| 2013 | 59 | |
| 2014 | 49 | |
| 2015 | 67 | |
| 2016 | 61 | |
| 2017 | 67 | |
| 2018 | 57 | |
| 2019 | 64 | |
| 2020 | 54 | |
| 2021 | 46 | |
| 2022 | 46 | |
| 2023 | 53 | |
| 2024 | 55 | |
| 2025 | 46 | |
Alaskan Malamute Pet Health Insights
Alaskan Malamute accounts for 837 FDA adverse event reports, ranking #116 by volume among dog breeds, with 40 reports (4.8%) coded as a death outcome. Mean age at report: 5.4 years, average weight 38.2 kg (84.2 lbs).
Top reported signs: Vomiting (149), Lethargy (see also Central nervous system depression in 'Neurological') (99), Diarrhoea (81). Most-referenced drug: Milbemycin Oxime + Spinosad (149 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (96) and Pyrantel Pamoate;Sarolaner (63).
Outcome coding on 784 status-recorded reports is dominated by Outcome Unknown (33.5%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Alaskan Malamute? ▼
There are 837 adverse event reports involving Alaskan Malamute in the FDA database, with 40 reports involving death (4.8% death rate). Alaskan Malamute ranks #116 by report volume.
What are the most common adverse reactions reported for Alaskan Malamute? ▼
The most commonly reported adverse reactions for Alaskan Malamute are Vomiting (149 reports), Lethargy (see also Central nervous system depression in 'Neurological') (99 reports), Diarrhoea (81 reports), Lack of efficacy - NOS (53 reports), Emesis (52 reports).
What drugs are most frequently associated with Alaskan Malamute adverse events? ▼
The drugs most frequently referenced in Alaskan Malamute adverse event reports are Milbemycin Oxime + Spinosad (149 reports), Ivermectin + Pyrantel As Pamoate Salt (96 reports), Pyrantel Pamoate;Sarolaner (63 reports), Afoxolaner (61 reports), Milbemycin Oxime + Praziquantel (44 reports).
What is the average age of Alaskan Malamute in adverse event reports? ▼
The average age of Alaskan Malamute at the time of adverse event reports is 5.4 years, with an average weight of 38.2 kg (84.2 lbs).
Does a high number of adverse event reports mean Alaskan Malamute is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Alaskan Malamute safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.