Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
913
Total Reports
79
Deaths Reported
870.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 26.2 kg (57.8 lbs)
Top Reported Reactions
Vomiting 124
Lack of efficacy (endoparasite) - heartworm 82
Lethargy (see also Central nervous system depression in Neurological) 81
Diarrhoea 69
Lack of efficacy - NOS 63
Seizure NOS 52
Lack of efficacy (ectoparasite) - flea 51
Death 43
Lack of efficacy (endoparasite) - hookworm 35
Hives (see also Skin) 33
Death by euthanasia 33
Panting 31
Medication error NOS 30
Polydipsia 29
Intentional misuse 26
Most Referenced Drugs
Bedinvetmab 203
Oclacitinib Maleate 129
Pyrantel Pamoate;Sarolaner 108
Moxidectin 77
Fluralaner 13.64% 12-Week Chew 64
Ivermectin + Pyrantel As Pamoate Salt 54
Carprofen 50
Afoxolaner 49
Anti-Il31 Mab Mcs Lot #1283563 45
Gabapentin 41
Prednisone 33
Milbemycin Oxime + Praziquantel 32
Cyclosporine 28
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 28
Ilunocitinib 28
Outcome Breakdown
Ongoing
409 (44.8%)
Outcome Unknown
257 (28.1%)
Recovered/Normal
164 (18.0%)
Died
46 (5.0%)
Euthanized
33 (3.6%)
Recovered with Sequela
4 (0.4%)
Gender Distribution
Female 450 (49.3%)
Male 442 (48.4%)
Unknown 19 (2.1%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 3 | |
| 2013 | 1 | |
| 2017 | 3 | |
| 2018 | 1 | |
| 2019 | 1 | |
| 2020 | 1 | |
| 2021 | 6 | |
| 2022 | 12 | |
| 2023 | 67 | |
| 2024 | 529 | |
| 2025 | 289 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #113 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.