Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
847
Total Reports
39
Deaths Reported
460.0%
Death Rate
6.9 yr
Avg Age at Report
Average weight at time of report: 8.4 kg (18.5 lbs)
Top Reported Reactions
Vomiting 208
Lethargy (see also Central nervous system depression in 'Neurological') 86
Diarrhoea 78
Lack of efficacy (ectoparasite) - flea 70
Emesis 67
Lack of efficacy (endoparasite) - hookworm 47
Lack of efficacy - NOS 47
Anorexia 45
Pruritus 30
Seizure NOS 30
Depression 28
INEFFECTIVE, HEARTWORM LARVAE 28
Other abnormal test result NOS 28
Behavioural disorder NOS 24
Digestive tract disorder NOS 24
Most Referenced Drugs
Milbemycin Oxime + Spinosad 124
Ivermectin + Pyrantel As Pamoate Salt 83
Spinosad 71
Afoxolaner 57
Oclacitinib Maleate 48
Fluralaner Chew Tablets 35
Afoxolaner 28.3 Mg Chewable Tablets 34
Moxidectin 31
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 21
Carprofen 19
Sarolaner 19
Selamectin 17
Pyrantel Pamoate;Sarolaner 17
Imidacloprid + Moxidectin 16
Ivermectin, Pyrantel 15
Outcome Breakdown
Recovered/Normal
259 (36.3%)
Outcome Unknown
240 (33.7%)
Ongoing
137 (19.2%)
Recovered with Sequela
38 (5.3%)
Died
20 (2.8%)
Euthanized
19 (2.7%)
Gender Distribution
Female 454 (53.6%)
Male 374 (44.2%)
Unknown 16 (1.9%)
Mixed 3 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 71 | |
| 2011 | 75 | |
| 2012 | 89 | |
| 2013 | 60 | |
| 2014 | 61 | |
| 2015 | 96 | |
| 2016 | 70 | |
| 2017 | 77 | |
| 2018 | 47 | |
| 2019 | 37 | |
| 2020 | 27 | |
| 2021 | 28 | |
| 2022 | 33 | |
| 2023 | 29 | |
| 2024 | 33 | |
| 2025 | 14 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #115 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.