Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,533
Total Reports
42
Deaths Reported
270.0%
Death Rate
4.9 yr
Avg Age at Report
Average weight at time of report: 24.1 kg (53.1 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 234
Vomiting 175
INEFFECTIVE, HEARTWORM LARVAE 173
Lack of efficacy (endoparasite) - hookworm 147
Lack of efficacy - NOS 122
Emesis 103
Lethargy (see also Central nervous system depression in 'Neurological') 92
Diarrhoea 75
Digestive tract disorder NOS 71
Lack of efficacy (ectoparasite) - flea 46
Lack of efficacy (endoparasite) - whipworm 42
Anorexia 42
INEFFECTIVE, HOOKS 42
INEFFECTIVE, ASCARIDS NOS 39
Cardiac disorder NOS 39
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 287
Milbemycin Oxime + Spinosad 241
Moxidectin 113
Milbemycin Oxime + Praziquantel 111
Pyrantel Pamoate;Sarolaner 99
Afoxolaner 84
Spinosad 50
Oclacitinib Maleate 48
Melarsomine Dihydrochloride 40
Bedinvetmab 38
Carprofen 29
Ivermectin 28
Sarolaner 27
Milbemycin 26
Ivermectin, Pyrantel 25
Outcome Breakdown
Outcome Unknown
590 (41.4%)
Ongoing
373 (26.2%)
Recovered/Normal
325 (22.8%)
Recovered with Sequela
95 (6.7%)
Died
22 (1.5%)
Euthanized
20 (1.4%)
Gender Distribution
Female 800 (52.2%)
Male 700 (45.7%)
Unknown 25 (1.6%)
Mixed 8 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 52 | |
| 2011 | 95 | |
| 2012 | 92 | |
| 2013 | 91 | |
| 2014 | 97 | |
| 2015 | 91 | |
| 2016 | 103 | |
| 2017 | 102 | |
| 2018 | 116 | |
| 2019 | 128 | |
| 2020 | 97 | |
| 2021 | 102 | |
| 2022 | 108 | |
| 2023 | 96 | |
| 2024 | 111 | |
| 2025 | 52 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #88 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.