Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
69
Total Reports
5
Deaths Reported
720.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 23.4 kg (51.6 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 15
Vomiting 11
Diarrhoea 6
Lethargy (see also Central nervous system depression in 'Neurological') 5
Ataxia 5
Emesis 4
Shaking 4
Pale mucous membrane 3
Behavioural disorder NOS 3
Death by euthanasia 3
Underdose 3
Lack of efficacy (ectoparasite) - flea 3
Lack of efficacy (endoparasite) - hookworm 2
Anaphylaxis 2
Other abnormal test result NOS 2
Most Referenced Drugs
Pyrantel Pamoate;Sarolaner 16
Milbemycin Oxime + Spinosad 9
Moxidectin 9
Milbemycin Oxime + Praziquantel 8
Ivermectin + Pyrantel As Pamoate Salt 8
Sarolaner 4
Carprofen 3
Grapiprant 3
Milbemycin Oxime 3
Bedinvetmab 3
Glucosamine 2
Nitenpyram 2
Ivermectin 2
Fluralaner 2
Fluralaner 13.64% 12-Week Chew 2
Outcome Breakdown
Ongoing
29 (42.0%)
Outcome Unknown
22 (31.9%)
Recovered/Normal
12 (17.4%)
Euthanized
3 (4.3%)
Died
2 (2.9%)
Recovered with Sequela
1 (1.4%)
Gender Distribution
Female 42 (60.9%)
Male 25 (36.2%)
Mixed 1 (1.4%)
Unknown 1 (1.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 1 | |
| 2013 | 2 | |
| 2014 | 3 | |
| 2015 | 3 | |
| 2016 | 3 | |
| 2017 | 3 | |
| 2018 | 5 | |
| 2019 | 7 | |
| 2020 | 8 | |
| 2021 | 7 | |
| 2022 | 3 | |
| 2023 | 9 | |
| 2024 | 7 | |
| 2025 | 8 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #249 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.