Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
34,475
Total Reports
1,286
Deaths Reported
370.0%
Death Rate
4.6 yr
Avg Age at Report
Average weight at time of report: 28.5 kg (62.8 lbs)
Top Reported Reactions
Vomiting 6,544
Lack of efficacy (endoparasite) - hookworm 2,976
Diarrhoea 2,920
Lethargy (see also Central nervous system depression in 'Neurological') 2,730
Emesis 2,011
Lack of efficacy - NOS 1,666
Digestive tract disorder NOS 1,645
Seizure NOS 1,558
Lack of efficacy (endoparasite) - heartworm 1,269
INEFFECTIVE, HEARTWORM LARVAE 1,262
Lack of efficacy (endoparasite) - roundworm NOS 1,242
Lack of efficacy (ectoparasite) - tick NOS 1,208
Lack of efficacy (bacteria) - Borrelia 1,170
Lack of efficacy (ectoparasite) - flea 1,094
INEFFECTIVE, ASCARIDS NOS 1,082
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,536
Ivermectin + Pyrantel As Pamoate Salt 4,645
Pyrantel Pamoate;Sarolaner 3,915
Afoxolaner 3,303
Milbemycin Oxime + Praziquantel 1,961
Moxidectin 1,503
Oclacitinib Maleate 1,263
Carprofen 1,091
Fluralaner Chew Tablets 1,006
Spinosad 961
Fluralaner 13.64% 12-Week Chew 955
Sarolaner 903
Bedinvetmab 895
Lotilaner 729
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 536
Outcome Breakdown
Outcome Unknown
11,108 (34.0%)
Recovered/Normal
9,987 (30.6%)
Ongoing
9,364 (28.7%)
Recovered with Sequela
889 (2.7%)
Euthanized
653 (2.0%)
Died
633 (1.9%)
Gender Distribution
Male 17,397 (50.5%)
Female 16,414 (47.6%)
Unknown 583 (1.7%)
Mixed 81 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1,016 | |
| 2011 | 1,117 | |
| 2012 | 1,686 | |
| 2013 | 1,899 | |
| 2014 | 1,931 | |
| 2015 | 2,131 | |
| 2016 | 2,231 | |
| 2017 | 2,476 | |
| 2018 | 2,245 | |
| 2019 | 2,378 | |
| 2020 | 2,323 | |
| 2021 | 2,391 | |
| 2022 | 2,494 | |
| 2023 | 2,790 | |
| 2024 | 3,280 | |
| 2025 | 2,087 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #5 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.