Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
569
Total Reports
23
Deaths Reported
400.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 31.5 kg (69.5 lbs)
Top Reported Reactions
Vomiting 143
Emesis 70
Diarrhoea 55
Lethargy (see also Central nervous system depression in 'Neurological') 44
Lack of efficacy (endoparasite) - hookworm 24
Lack of efficacy - NOS 21
Lack of efficacy (ectoparasite) - tick NOS 20
Anorexia 19
Lack of efficacy (bacteria) - Borrelia 19
Lack of efficacy (endoparasite) - roundworm NOS 17
Lack of efficacy (ectoparasite) - flea 16
Seizure NOS 16
Emesis (multiple) 16
Weight loss 14
Other abnormal test result NOS 14
Most Referenced Drugs
Milbemycin Oxime + Spinosad 133
Ivermectin + Pyrantel As Pamoate Salt 48
Pyrantel Pamoate;Sarolaner 42
Spinosad 39
Afoxolaner 33
Carprofen 32
Fluralaner Chew Tablets 31
Moxidectin 29
Milbemycin Oxime + Praziquantel 28
Oclacitinib Maleate 19
Fluralaner 13.64% 12-Week Chew 16
Sarolaner 15
Lotilaner 11
Milbemycin Oxime 9
Imidacloprid + Moxidectin 9
Outcome Breakdown
Recovered/Normal
202 (38.9%)
Outcome Unknown
140 (27.0%)
Ongoing
127 (24.5%)
Recovered with Sequela
27 (5.2%)
Died
12 (2.3%)
Euthanized
11 (2.1%)
Gender Distribution
Male 313 (55.0%)
Female 253 (44.5%)
Unknown 2 (0.4%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 30 | |
| 2011 | 22 | |
| 2012 | 54 | |
| 2013 | 59 | |
| 2014 | 30 | |
| 2015 | 48 | |
| 2016 | 38 | |
| 2017 | 49 | |
| 2018 | 27 | |
| 2019 | 43 | |
| 2020 | 48 | |
| 2021 | 48 | |
| 2022 | 39 | |
| 2023 | 34 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #130 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.