Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
63
Total Reports
5
Deaths Reported
790.0%
Death Rate
7.0 yr
Avg Age at Report
Average weight at time of report: 9.1 kg (20.1 lbs)
Top Reported Reactions
Vomiting 10
Emesis 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Seizure NOS 7
Anorexia 6
Diarrhoea 5
Lack of efficacy - NOS 4
Weight loss 4
Elevated blood urea nitrogen (BUN) 4
Elevated creatinine 4
Death by euthanasia 3
Lack of efficacy (ectoparasite) - flea 3
Twitching 2
Anaemia NOS 2
Death 2
Most Referenced Drugs
Milbemycin Oxime + Spinosad 9
Fluralaner Chew Tablets 8
Spinosad 7
Nitenpyram 4
Oclacitinib Maleate 4
Afoxolaner 4
Ivermectin + Pyrantel As Pamoate Salt 3
Pyrantel Pamoate;Sarolaner 3
Allergy Tablet (Unknown) 2
Maropitant Citrate 2
Vaccine 2
Sarolaner 2
Dinotefuran + Pyriproxyfen 2
Betamethasone + Florfenicol + Terbinafine 2
Milbemycin Oxime + Praziquantel 2
Outcome Breakdown
Recovered/Normal
24 (40.7%)
Outcome Unknown
15 (25.4%)
Ongoing
13 (22.0%)
Euthanized
3 (5.1%)
Died
2 (3.4%)
Recovered with Sequela
2 (3.4%)
Gender Distribution
Female 33 (52.4%)
Male 30 (47.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2011 | 5 | |
| 2012 | 6 | |
| 2013 | 6 | |
| 2014 | 1 | |
| 2015 | 6 | |
| 2016 | 8 | |
| 2017 | 13 | |
| 2018 | 4 | |
| 2019 | 5 | |
| 2020 | 4 | |
| 2022 | 1 | |
| 2023 | 1 | |
| 2025 | 1 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #259 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.