Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
88
Total Reports
5
Deaths Reported
570.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 34.3 kg (75.6 lbs)
Top Reported Reactions
Vomiting 23
Lethargy (see also Central nervous system depression in 'Neurological') 9
Diarrhoea 8
Emesis 8
INEFFECTIVE, ASCARIDS NOS 6
Lack of efficacy (ectoparasite) - flea 6
Digestive tract disorder NOS 5
Lack of efficacy (endoparasite) - hookworm 5
Death 4
Anorexia 4
Seizure NOS 4
Ataxia 4
Lack of efficacy (endoparasite) - roundworm NOS 4
Lack of efficacy (endoparasite) - whipworm 3
Lack of efficacy - NOS 3
Most Referenced Drugs
Milbemycin Oxime + Spinosad 13
Ivermectin + Pyrantel As Pamoate Salt 11
Afoxolaner 7
Spinosad 6
Fluralaner 13.64% 12-Week Chew 6
Bedinvetmab 6
Carprofen 5
Milbemycin Oxime + Praziquantel 5
Lotilaner 5
Milbemycin Oxime 5
Milbemycin 4
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 2
Selamectin 2
Nitenpyram 2
Omeprazole 2
Outcome Breakdown
Recovered/Normal
29 (38.2%)
Outcome Unknown
24 (31.6%)
Ongoing
17 (22.4%)
Died
4 (5.3%)
Recovered with Sequela
1 (1.3%)
Euthanized
1 (1.3%)
Gender Distribution
Male 50 (56.8%)
Female 37 (42.0%)
Unknown 1 (1.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 7 | |
| 2011 | 6 | |
| 2012 | 3 | |
| 2013 | 9 | |
| 2014 | 6 | |
| 2015 | 4 | |
| 2016 | 6 | |
| 2017 | 2 | |
| 2018 | 5 | |
| 2019 | 5 | |
| 2020 | 2 | |
| 2021 | 6 | |
| 2022 | 5 | |
| 2023 | 3 | |
| 2024 | 11 | |
| 2025 | 8 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #238 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.