Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
5,328
Total Reports
188
Deaths Reported
350.0%
Death Rate
6.5 yr
Avg Age at Report
Average weight at time of report: 6.7 kg (14.8 lbs)
Top Reported Reactions
Vomiting 1,293
Lethargy (see also Central nervous system depression in 'Neurological') 590
Diarrhoea 469
Emesis 464
Lack of efficacy (ectoparasite) - flea 328
Seizure NOS 262
Lack of efficacy (endoparasite) - hookworm 261
Anorexia 223
Lack of efficacy - NOS 218
Emesis (multiple) 166
Digestive tract disorder NOS 160
Behavioural disorder NOS 157
Other abnormal test result NOS 149
Decreased appetite 141
Not eating 134
Most Referenced Drugs
Milbemycin Oxime + Spinosad 728
Ivermectin + Pyrantel As Pamoate Salt 589
Afoxolaner 509
Trilostane 311
Fluralaner Chew Tablets 258
Pyrantel Pamoate;Sarolaner 244
Spinosad 243
Fluralaner 13.64% 12-Week Chew 177
Imidacloprid + Moxidectin 162
Moxidectin 150
Milbemycin Oxime + Praziquantel 150
Oclacitinib Maleate 123
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 111
Lufenuron + Milbemycin Oxime 94
Afoxolaner 28.3 Mg Chewable Tablets 93
Outcome Breakdown
Recovered/Normal
2,054 (38.5%)
Outcome Unknown
1,839 (34.5%)
Ongoing
1,099 (20.6%)
Recovered with Sequela
151 (2.8%)
Died
95 (1.8%)
Euthanized
94 (1.8%)
Gender Distribution
Male 2,717 (51.0%)
Female 2,483 (46.6%)
Unknown 117 (2.2%)
Mixed 11 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 6 | |
| 2011 | 73 | |
| 2012 | 332 | |
| 2013 | 433 | |
| 2014 | 406 | |
| 2015 | 471 | |
| 2016 | 442 | |
| 2017 | 489 | |
| 2018 | 410 | |
| 2019 | 397 | |
| 2020 | 358 | |
| 2021 | 297 | |
| 2022 | 286 | |
| 2023 | 329 | |
| 2024 | 375 | |
| 2025 | 224 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #38 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.