Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
559
Total Reports
27
Deaths Reported
480.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 20.7 kg (45.6 lbs)
Top Reported Reactions
Vomiting 98
Lack of efficacy (endoparasite) - heartworm 85
Lethargy (see also Central nervous system depression in 'Neurological') 50
Diarrhoea 39
Lack of efficacy - NOS 35
Seizure NOS 28
Emesis 22
Lack of efficacy (ectoparasite) - flea 18
Panting 18
Lack of efficacy (endoparasite) - hookworm 18
Behavioural disorder NOS 16
Elevated alanine aminotransferase (ALT) 16
Lethargy (see also Central nervous system depression in Neurological) 16
Decreased appetite 15
Death 15
Most Referenced Drugs
Moxidectin 107
Milbemycin Oxime + Spinosad 90
Pyrantel Pamoate;Sarolaner 82
Milbemycin Oxime + Praziquantel 47
Oclacitinib Maleate 43
Bedinvetmab 31
Sarolaner 29
Melarsomine Dihydrochloride 27
Carprofen 24
Maropitant Citrate 22
Selamectin 16
Lotilaner 15
Gabapentin 14
Spinosad 13
Dexmedetomidine Hydrochloride 13
Outcome Breakdown
Ongoing
264 (47.2%)
Recovered/Normal
143 (25.6%)
Outcome Unknown
116 (20.8%)
Died
18 (3.2%)
Recovered with Sequela
9 (1.6%)
Euthanized
9 (1.6%)
Gender Distribution
Female 310 (55.5%)
Male 240 (42.9%)
Unknown 7 (1.3%)
Mixed 2 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 15 | |
| 2013 | 33 | |
| 2014 | 30 | |
| 2015 | 17 | |
| 2016 | 34 | |
| 2017 | 43 | |
| 2018 | 40 | |
| 2019 | 36 | |
| 2020 | 59 | |
| 2021 | 71 | |
| 2022 | 43 | |
| 2023 | 50 | |
| 2024 | 62 | |
| 2025 | 26 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #133 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.