Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
529
Total Reports
33
Deaths Reported
620.0%
Death Rate
3.8 yr
Avg Age at Report
Average weight at time of report: 46.4 kg (102.3 lbs)
Top Reported Reactions
Vomiting 103
Emesis 58
Lethargy (see also Central nervous system depression in 'Neurological') 47
Diarrhoea 43
Lack of efficacy (endoparasite) - heartworm 33
INEFFECTIVE, HEARTWORM LARVAE 31
Anorexia 26
Lack of efficacy (ectoparasite) - flea 25
Digestive tract disorder NOS 25
Lack of efficacy (endoparasite) - hookworm 23
Lack of efficacy - NOS 22
Seizure NOS 20
Underdose 19
Death by euthanasia 19
Not eating 16
Most Referenced Drugs
Milbemycin Oxime + Spinosad 141
Ivermectin + Pyrantel As Pamoate Salt 83
Spinosad 39
Milbemycin Oxime + Praziquantel 35
Carprofen 34
Afoxolaner 23
Oclacitinib Maleate 22
Fluralaner Chew Tablets 21
Pyrantel Pamoate;Sarolaner 20
Moxidectin 17
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 13
Bedinvetmab 13
Gabapentin 10
Grapiprant 10
Selamectin 9
Outcome Breakdown
Recovered/Normal
170 (34.6%)
Outcome Unknown
169 (34.4%)
Ongoing
101 (20.6%)
Euthanized
19 (3.9%)
Recovered with Sequela
18 (3.7%)
Died
14 (2.9%)
Gender Distribution
Male 283 (53.5%)
Female 226 (42.7%)
Unknown 17 (3.2%)
Mixed 3 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 14 | |
| 2011 | 32 | |
| 2012 | 40 | |
| 2013 | 34 | |
| 2014 | 49 | |
| 2015 | 48 | |
| 2016 | 49 | |
| 2017 | 48 | |
| 2018 | 42 | |
| 2019 | 31 | |
| 2020 | 29 | |
| 2021 | 25 | |
| 2022 | 25 | |
| 2023 | 16 | |
| 2024 | 31 | |
| 2025 | 16 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #136 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.