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2026 FDA CVM data 1,271 reports on file official source

Shepherd Dog (unspecified) — FDA Adverse Event Profile

Adverse-event records and label data for Shepherd Dog (unspecified) (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 140 105 70 35 0 2018 2019 2020 2021 2022 2023 2024 2025 Reports filed Death-coded reports
Annual report volume for Shepherd Dog (unspecified) drawn from FDA CVM filings.

Shepherd Dog (unspecified) (Dog) has 1,271 FDA adverse event reports on record, with 41 deaths reported (320.0% death rate) — ranking #95 by report volume. The most frequently reported reaction is Lack of efficacy (endoparasite) - heartworm (248 cases). The top associated drug is Ivermectin + Pyrantel As Pamoate Salt. Average age at report: 4.5 years.

Total Reports

1,271

FDA CVM filings

Deaths Reported

41

of 1,271 reports

Death Rate

320.0%

death-coded share

Avg Age at Report

4.5 yr

27.0 kg avg weight

Death-Coded Outcome Share

Shepherd Dog (unspecified) death-coded reports 100.0%
Database median

320.0% of 1,271 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 27.0 kg (59.5 lbs)

Top Reported Reactions

Lack of efficacy (endoparasite) - heartworm 248
Vomiting 197
Emesis 179
Lethargy (see also Central nervous system depression in 'Neurological') 90
INEFFECTIVE, HEARTWORM LARVAE 69
Diarrhoea 67
Lack of efficacy (endoparasite) - hookworm 66
Lack of efficacy - NOS 58
INEFFECTIVE, HOOKS 45
Lack of efficacy (endoparasite) - roundworm NOS 38
Lack of efficacy (ectoparasite) - tick NOS 37
Seizure NOS 35
Lack of efficacy (ectoparasite) - flea 34
Lack of efficacy (bacteria) - NOS 28
Other abnormal test result NOS 27

Most Referenced Drugs

Ivermectin + Pyrantel As Pamoate Salt 411
Milbemycin Oxime + Spinosad 387
Afoxolaner 181
Milbemycin Oxime + Praziquantel 128
Spinosad 71
Grapiprant 26
Melarsomine Dihydrochloride 24
Lotilaner 21
Milbemycin Oxime 18
Ivermectin 16
Carprofen 15
Recombitek Lyme - 2126.R0 13
Fluralaner 13.64% 12-Week Chew 13
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 12
Levothyroxine Sodium 10

Outcome Breakdown

Outcome Unknown
527 (41.4%)
Recovered/Normal
418 (32.9%)
Ongoing
171 (13.4%)
Recovered with Sequela
115 (9.0%)
Died
23 (1.8%)
Euthanized
18 (1.4%)

Gender Distribution

Female 696 (54.8%)
Male 553 (43.5%)
Unknown 18 (1.4%)
Mixed 4 (0.3%)

Reports by Year

Year Reports Trend
2010 1
2011 4
2012 54
2013 120
2014 87
2015 54
2016 70
2017 100
2018 127
2019 140
2020 126
2021 110
2022 83
2023 77
2024 71
2025 47
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Shepherd Dog (unspecified) sits in the registered size-class taxonomy. Average reported weight: 27.0 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Shepherd Dog (unspecified) Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Shepherd Dog (unspecified) accounts for 1,271 submitted reports and currently ranks #95 by report volume within the dog population. Of those reports, 41 involved a death outcome — a 320.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 4.5 years, with an average recorded body weight of 27.0 kg (59.5 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Shepherd Dog (unspecified) are Lack of efficacy (endoparasite) - heartworm (248 reports), Vomiting (197 reports), Emesis (179 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Ivermectin + Pyrantel As Pamoate Salt appears in 411 reports and is the single most-referenced drug, followed by Milbemycin Oxime + Spinosad (387) and Afoxolaner (181). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 1,272 reports with a recorded status is dominated by Outcome Unknown (41.4% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.

Understanding Shepherd Dog (unspecified) Adverse Event Data

Shepherd Dog (unspecified) has a moderate volume of adverse event reports (1,271). Report counts are influenced by breed popularity, owner awareness, and veterinary reporting practices.

The 320.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Ivermectin + Pyrantel As Pamoate Salt, appearing in 411 reports. This may indicate widespread use of the medication rather than a specific safety concern for Shepherd Dog (unspecified).

Other Dog Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Shepherd Dog (unspecified)?
There are 1,271 adverse event reports involving Shepherd Dog (unspecified) in the FDA database, with 41 reports involving death (320.0% death rate). Shepherd Dog (unspecified) ranks #95 by report volume.
What are the most common adverse reactions reported for Shepherd Dog (unspecified)?
The most commonly reported adverse reactions for Shepherd Dog (unspecified) are Lack of efficacy (endoparasite) - heartworm (248 reports), Vomiting (197 reports), Emesis (179 reports), Lethargy (see also Central nervous system depression in 'Neurological') (90 reports), INEFFECTIVE, HEARTWORM LARVAE (69 reports).
What drugs are most frequently associated with Shepherd Dog (unspecified) adverse events?
The drugs most frequently referenced in Shepherd Dog (unspecified) adverse event reports are Ivermectin + Pyrantel As Pamoate Salt (411 reports), Milbemycin Oxime + Spinosad (387 reports), Afoxolaner (181 reports), Milbemycin Oxime + Praziquantel (128 reports), Spinosad (71 reports).
What is the average age of Shepherd Dog (unspecified) in adverse event reports?
The average age of Shepherd Dog (unspecified) at the time of adverse event reports is 4.5 years, with an average weight of 27.0 kg (59.5 lbs).
Does a high number of adverse event reports mean Shepherd Dog (unspecified) is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shepherd Dog (unspecified) safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Shepherd Dog (unspecified) ranks #95 by total report volume. Death rate (320.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial