Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,271
Total Reports
41
Deaths Reported
320.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 27.0 kg (59.5 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 248
Vomiting 197
Emesis 179
Lethargy (see also Central nervous system depression in 'Neurological') 90
INEFFECTIVE, HEARTWORM LARVAE 69
Diarrhoea 67
Lack of efficacy (endoparasite) - hookworm 66
Lack of efficacy - NOS 58
INEFFECTIVE, HOOKS 45
Lack of efficacy (endoparasite) - roundworm NOS 38
Lack of efficacy (ectoparasite) - tick NOS 37
Seizure NOS 35
Lack of efficacy (ectoparasite) - flea 34
Lack of efficacy (bacteria) - NOS 28
Other abnormal test result NOS 27
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 411
Milbemycin Oxime + Spinosad 387
Afoxolaner 181
Milbemycin Oxime + Praziquantel 128
Spinosad 71
Grapiprant 26
Melarsomine Dihydrochloride 24
Lotilaner 21
Milbemycin Oxime 18
Ivermectin 16
Carprofen 15
Recombitek Lyme - 2126.R0 13
Fluralaner 13.64% 12-Week Chew 13
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 12
Levothyroxine Sodium 10
Outcome Breakdown
Outcome Unknown
527 (41.4%)
Recovered/Normal
418 (32.9%)
Ongoing
171 (13.4%)
Recovered with Sequela
115 (9.0%)
Died
23 (1.8%)
Euthanized
18 (1.4%)
Gender Distribution
Female 696 (54.8%)
Male 553 (43.5%)
Unknown 18 (1.4%)
Mixed 4 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 4 | |
| 2012 | 54 | |
| 2013 | 120 | |
| 2014 | 87 | |
| 2015 | 54 | |
| 2016 | 70 | |
| 2017 | 100 | |
| 2018 | 127 | |
| 2019 | 140 | |
| 2020 | 126 | |
| 2021 | 110 | |
| 2022 | 83 | |
| 2023 | 77 | |
| 2024 | 71 | |
| 2025 | 47 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #95 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.