Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
455
Total Reports
13
Deaths Reported
290.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 27.0 kg (59.5 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 95
Lack of efficacy (endoparasite) - hookworm 79
Vomiting 57
INEFFECTIVE, HOOKS 30
Diarrhoea 26
Lack of efficacy (ectoparasite) - flea 24
INEFFECTIVE, HEARTWORM LARVAE 21
Emesis 21
Lack of efficacy - NOS 18
Other abnormal test result NOS 15
Lethargy (see also Central nervous system depression in 'Neurological') 14
Digestive tract disorder NOS 12
Lack of efficacy (endoparasite) - roundworm NOS 12
Behavioural disorder NOS 11
Lack of efficacy (ectoparasite) - tick NOS 11
Most Referenced Drugs
Milbemycin Oxime + Praziquantel 75
Moxidectin 68
Milbemycin Oxime + Spinosad 67
Ivermectin + Pyrantel As Pamoate Salt 63
Spinosad 46
Pyrantel Pamoate;Sarolaner 45
Afoxolaner 18
Pyrantel Pamoate 16
Ivermectin 12
Oclacitinib Maleate 12
Melarsomine Dihydrochloride 11
Lotilaner 11
Fluralaner 13.64% 12-Week Chew 10
Milbemycin Oxime 9
Sarolaner 8
Outcome Breakdown
Outcome Unknown
180 (39.6%)
Ongoing
161 (35.4%)
Recovered/Normal
89 (19.6%)
Recovered with Sequela
12 (2.6%)
Died
7 (1.5%)
Euthanized
6 (1.3%)
Gender Distribution
Male 249 (54.7%)
Female 198 (43.5%)
Unknown 7 (1.5%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 2 | |
| 2012 | 13 | |
| 2013 | 31 | |
| 2014 | 22 | |
| 2015 | 15 | |
| 2016 | 24 | |
| 2017 | 21 | |
| 2018 | 31 | |
| 2019 | 37 | |
| 2020 | 37 | |
| 2021 | 40 | |
| 2022 | 37 | |
| 2023 | 51 | |
| 2024 | 50 | |
| 2025 | 44 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #143 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.