Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,700
Total Reports
189
Deaths Reported
510.0%
Death Rate
6.8 yr
Avg Age at Report
Average weight at time of report: 6.6 kg (14.6 lbs)
Top Reported Reactions
Vomiting 686
Lethargy (see also Central nervous system depression in 'Neurological') 433
Emesis 296
Diarrhoea 283
Lack of efficacy (ectoparasite) - flea 242
Lack of efficacy - NOS 218
Anorexia 163
Seizure NOS 159
INEFFECTIVE, HEARTWORM LARVAE 155
Lack of efficacy (endoparasite) - heartworm 139
Ataxia 137
Other abnormal test result NOS 133
Behavioural disorder NOS 122
Lack of efficacy (endoparasite) - hookworm 118
Elevated alanine aminotransferase (ALT) 105
Most Referenced Drugs
Milbemycin Oxime + Spinosad 705
Spinosad 337
Ivermectin + Pyrantel As Pamoate Salt 296
Afoxolaner 201
Moxidectin 152
Fluralaner Chew Tablets 136
Trilostane 131
Insulin Injectable Vial 122
Oclacitinib Maleate 102
Pyrantel Pamoate;Sarolaner 96
Milbemycin Oxime + Praziquantel 77
Carprofen 75
Sarolaner 70
Fluralaner 13.64% 12-Week Chew 70
Nitenpyram 67
Outcome Breakdown
Recovered/Normal
1,131 (33.9%)
Outcome Unknown
1,097 (32.9%)
Ongoing
750 (22.5%)
Recovered with Sequela
171 (5.1%)
Died
100 (3.0%)
Euthanized
89 (2.7%)
Gender Distribution
Female 1,848 (49.9%)
Male 1,770 (47.8%)
Unknown 74 (2.0%)
Mixed 8 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 176 | |
| 2011 | 245 | |
| 2012 | 299 | |
| 2013 | 325 | |
| 2014 | 362 | |
| 2015 | 304 | |
| 2016 | 307 | |
| 2017 | 294 | |
| 2018 | 275 | |
| 2019 | 234 | |
| 2020 | 203 | |
| 2021 | 154 | |
| 2022 | 159 | |
| 2023 | 147 | |
| 2024 | 138 | |
| 2025 | 78 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #54 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.