Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
10,210
Total Reports
375
Deaths Reported
370.0%
Death Rate
6.8 yr
Avg Age at Report
Average weight at time of report: 8.6 kg (19.0 lbs)
Top Reported Reactions
Vomiting 2,152
Lethargy (see also Central nervous system depression in 'Neurological') 1,033
Emesis 1,013
Lack of efficacy (ectoparasite) - flea 957
Diarrhoea 676
Lack of efficacy - NOS 603
INEFFECTIVE, HEARTWORM LARVAE 478
Lack of efficacy (endoparasite) - hookworm 439
Seizure NOS 435
Lack of efficacy (endoparasite) - heartworm 432
Anorexia 350
Pruritus 282
Behavioural disorder NOS 280
Digestive tract disorder NOS 261
Shaking 252
Most Referenced Drugs
Milbemycin Oxime + Spinosad 2,175
Spinosad 1,043
Ivermectin + Pyrantel As Pamoate Salt 872
Afoxolaner 641
Moxidectin 488
Fluralaner Chew Tablets 442
Oclacitinib Maleate 424
Pyrantel Pamoate;Sarolaner 384
Trilostane 312
Milbemycin Oxime + Praziquantel 264
Fluralaner 13.64% 12-Week Chew 221
Nitenpyram 201
Sarolaner 198
Carprofen 195
Selamectin 154
Outcome Breakdown
Recovered/Normal
3,261 (35.1%)
Outcome Unknown
3,155 (34.0%)
Ongoing
2,081 (22.4%)
Recovered with Sequela
407 (4.4%)
Died
194 (2.1%)
Euthanized
181 (2.0%)
Gender Distribution
Male 5,123 (50.2%)
Female 4,856 (47.6%)
Unknown 206 (2.0%)
Mixed 25 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 505 | |
| 2011 | 675 | |
| 2012 | 854 | |
| 2013 | 839 | |
| 2014 | 817 | |
| 2015 | 913 | |
| 2016 | 864 | |
| 2017 | 780 | |
| 2018 | 680 | |
| 2019 | 627 | |
| 2020 | 575 | |
| 2021 | 482 | |
| 2022 | 415 | |
| 2023 | 448 | |
| 2024 | 449 | |
| 2025 | 287 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #18 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.