Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
150
Total Reports
2
Deaths Reported
130.0%
Death Rate
7.5 yr
Avg Age at Report
Average weight at time of report: 13.0 kg (28.7 lbs)
Top Reported Reactions
Vomiting 27
Emesis 11
Lack of efficacy (endoparasite) - heartworm 11
Lack of efficacy (ectoparasite) - flea 10
INEFFECTIVE, HEARTWORM LARVAE 7
Ataxia 7
Seizure NOS 7
Deafness 5
Lack of efficacy (endoparasite) - hookworm 5
Diarrhoea 5
Pruritus 5
Lack of efficacy - NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 4
Emesis (multiple) 4
Depression 3
Most Referenced Drugs
Milbemycin Oxime + Spinosad 23
Spinosad 16
Pyrantel Pamoate;Sarolaner 13
Fluralaner Chew Tablets 11
Moxidectin 9
Ivermectin + Pyrantel As Pamoate Salt 9
Milbemycin Oxime + Praziquantel 7
Carprofen 6
Sarolaner 5
Fluralaner 13.64% 12-Week Chew 5
Melarsomine Dihydrochloride 4
Ivermectin 4
Bedinvetmab 4
Ivermectin, Pyrantel 3
Maropitant Citrate 3
Outcome Breakdown
Ongoing
45 (34.6%)
Recovered/Normal
44 (33.8%)
Outcome Unknown
28 (21.5%)
Recovered with Sequela
11 (8.5%)
Died
2 (1.5%)
Gender Distribution
Male 73 (48.7%)
Female 73 (48.7%)
Unknown 3 (2.0%)
Mixed 1 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 12 | |
| 2011 | 9 | |
| 2012 | 14 | |
| 2013 | 12 | |
| 2014 | 6 | |
| 2015 | 6 | |
| 2016 | 7 | |
| 2017 | 8 | |
| 2018 | 16 | |
| 2019 | 15 | |
| 2020 | 6 | |
| 2021 | 6 | |
| 2022 | 9 | |
| 2023 | 8 | |
| 2024 | 13 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #206 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.