Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,461
Total Reports
85
Deaths Reported
580.0%
Death Rate
6.6 yr
Avg Age at Report
Average weight at time of report: 10.7 kg (23.6 lbs)
Top Reported Reactions
Vomiting 259
Emesis 170
Lethargy (see also Central nervous system depression in 'Neurological') 154
Diarrhoea 129
Lack of efficacy (endoparasite) - hookworm 88
Lack of efficacy - NOS 81
Elevated serum alkaline phosphatase (SAP) 75
Lack of efficacy (endoparasite) - whipworm 57
Anorexia 54
Lack of efficacy (ectoparasite) - flea 53
Death by euthanasia 51
Elevated alanine aminotransferase (ALT) 51
Other abnormal test result NOS 51
Digestive tract disorder NOS 49
Deafness 47
Most Referenced Drugs
Milbemycin Oxime + Spinosad 293
Ivermectin + Pyrantel As Pamoate Salt 130
Oclacitinib Maleate 116
Spinosad 114
Afoxolaner 77
Trilostane 69
Milbemycin Oxime + Praziquantel 51
Pyrantel Pamoate;Sarolaner 47
Fluralaner Chew Tablets 45
Cyclosporine 32
Cyclosporine A 31
Milbemycin 30
Moxidectin 30
Selamectin 26
Prednisone 23
Outcome Breakdown
Recovered/Normal
469 (35.9%)
Outcome Unknown
396 (30.3%)
Ongoing
285 (21.8%)
Recovered with Sequela
70 (5.4%)
Euthanized
47 (3.6%)
Died
38 (2.9%)
Gender Distribution
Male 733 (50.2%)
Female 688 (47.1%)
Unknown 33 (2.3%)
Mixed 7 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 78 | |
| 2011 | 122 | |
| 2012 | 146 | |
| 2013 | 148 | |
| 2014 | 148 | |
| 2015 | 123 | |
| 2016 | 132 | |
| 2017 | 87 | |
| 2018 | 78 | |
| 2019 | 73 | |
| 2020 | 59 | |
| 2021 | 58 | |
| 2022 | 60 | |
| 2023 | 53 | |
| 2024 | 64 | |
| 2025 | 32 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #90 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.