Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
141
Total Reports
9
Deaths Reported
640.0%
Death Rate
3.9 yr
Avg Age at Report
Average weight at time of report: 44.3 kg (97.7 lbs)
Top Reported Reactions
Vomiting 29
Emesis 16
Seizure NOS 12
Lethargy (see also Central nervous system depression in 'Neurological') 11
Diarrhoea 10
Lack of efficacy (endoparasite) - heartworm 9
Lack of efficacy - NOS 7
Lack of efficacy (ectoparasite) - tick NOS 7
Ataxia 7
Anorexia 6
Other abnormal test result NOS 6
Death 5
Lack of efficacy (ectoparasite) - flea 5
Decreased appetite 5
Skin disorders NOS 4
Most Referenced Drugs
Milbemycin Oxime + Spinosad 39
Oclacitinib Maleate 13
Moxidectin 10
Pyrantel Pamoate;Sarolaner 10
Fluralaner 13.64% 12-Week Chew 9
Bedinvetmab 7
Fluralaner Chew Tablets 6
Ivermectin + Pyrantel As Pamoate Salt 6
Spinosad 5
Selamectin 5
Sarolaner 5
Prednisone 4
Carprofen 4
Milbemycin Oxime + Praziquantel 4
Afoxolaner 3
Outcome Breakdown
Ongoing
50 (35.7%)
Recovered/Normal
49 (35.0%)
Outcome Unknown
30 (21.4%)
Died
5 (3.6%)
Euthanized
4 (2.9%)
Recovered with Sequela
2 (1.4%)
Gender Distribution
Male 79 (56.0%)
Female 60 (42.6%)
Unknown 2 (1.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 3 | |
| 2012 | 4 | |
| 2013 | 12 | |
| 2014 | 9 | |
| 2015 | 11 | |
| 2016 | 17 | |
| 2017 | 7 | |
| 2018 | 10 | |
| 2019 | 14 | |
| 2020 | 12 | |
| 2021 | 5 | |
| 2022 | 9 | |
| 2023 | 10 | |
| 2024 | 15 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #213 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.