Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
452
Total Reports
25
Deaths Reported
550.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 15.0 kg (33.1 lbs)
Top Reported Reactions
Vomiting 109
Lethargy (see also Central nervous system depression in 'Neurological') 42
Emesis 41
Diarrhoea 33
INEFFECTIVE, HEARTWORM LARVAE 28
Lack of efficacy (endoparasite) - heartworm 24
Seizure NOS 22
Lack of efficacy - NOS 22
Anorexia 18
Lack of efficacy (endoparasite) - hookworm 16
Lack of efficacy (ectoparasite) - flea 14
Death by euthanasia 11
Death 11
Digestive tract disorder NOS 11
Elevated alanine aminotransferase (ALT) 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 86
Ivermectin + Pyrantel As Pamoate Salt 57
Afoxolaner 39
Spinosad 33
Moxidectin 23
Pyrantel Pamoate;Sarolaner 22
Fluralaner Chew Tablets 21
Milbemycin Oxime + Praziquantel 16
Trilostane 13
Oclacitinib Maleate 11
Milbemycin Oxime 10
Selamectin 10
Sarolaner 10
Bedinvetmab 10
Ivermectin 8
Outcome Breakdown
Recovered/Normal
175 (40.0%)
Outcome Unknown
125 (28.5%)
Ongoing
94 (21.5%)
Recovered with Sequela
19 (4.3%)
Died
14 (3.2%)
Euthanized
11 (2.5%)
Gender Distribution
Female 255 (56.4%)
Male 188 (41.6%)
Unknown 6 (1.3%)
Mixed 3 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 13 | |
| 2011 | 13 | |
| 2012 | 29 | |
| 2013 | 23 | |
| 2014 | 34 | |
| 2015 | 35 | |
| 2016 | 41 | |
| 2017 | 42 | |
| 2018 | 44 | |
| 2019 | 48 | |
| 2020 | 25 | |
| 2021 | 20 | |
| 2022 | 22 | |
| 2023 | 19 | |
| 2024 | 30 | |
| 2025 | 14 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #144 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.