Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,845
Total Reports
80
Deaths Reported
210.0%
Death Rate
4.9 yr
Avg Age at Report
Average weight at time of report: 6.3 kg (13.9 lbs)
Top Reported Reactions
Vomiting 1,141
Lethargy (see also Central nervous system depression in 'Neurological') 419
Diarrhoea 411
Emesis 371
Lack of efficacy (ectoparasite) - flea 209
Lack of efficacy (endoparasite) - hookworm 185
Seizure NOS 151
Anorexia 148
Lack of efficacy - NOS 142
Emesis (multiple) 123
Behavioural disorder NOS 119
Digestive tract disorder NOS 96
Shaking 92
Decreased appetite 84
Lethargy (see also Central nervous system depression in Neurological) 82
Most Referenced Drugs
Milbemycin Oxime + Spinosad 729
Ivermectin + Pyrantel As Pamoate Salt 410
Afoxolaner 364
Pyrantel Pamoate;Sarolaner 287
Spinosad 210
Moxidectin 199
Fluralaner Chew Tablets 181
Oclacitinib Maleate 146
Fluralaner 13.64% 12-Week Chew 132
Milbemycin Oxime + Praziquantel 127
Sarolaner 108
Trilostane 83
Selamectin 80
Lotilaner 62
Carprofen 60
Outcome Breakdown
Recovered/Normal
1,669 (44.9%)
Outcome Unknown
1,069 (28.8%)
Ongoing
812 (21.9%)
Recovered with Sequela
84 (2.3%)
Died
46 (1.2%)
Euthanized
34 (0.9%)
Gender Distribution
Male 2,046 (53.2%)
Female 1,727 (44.9%)
Unknown 63 (1.6%)
Mixed 9 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 56 | |
| 2011 | 120 | |
| 2012 | 239 | |
| 2013 | 214 | |
| 2014 | 252 | |
| 2015 | 266 | |
| 2016 | 308 | |
| 2017 | 271 | |
| 2018 | 324 | |
| 2019 | 278 | |
| 2020 | 264 | |
| 2021 | 271 | |
| 2022 | 280 | |
| 2023 | 250 | |
| 2024 | 274 | |
| 2025 | 178 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #52 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.