Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,455
Total Reports
140
Deaths Reported
310.0%
Death Rate
4.8 yr
Avg Age at Report
Average weight at time of report: 22.3 kg (49.2 lbs)
Top Reported Reactions
Vomiting 1,018
Lethargy (see also Central nervous system depression in 'Neurological') 433
Diarrhoea 423
Lack of efficacy (endoparasite) - hookworm 333
Emesis 313
Seizure NOS 223
Lack of efficacy - NOS 176
Lack of efficacy (ectoparasite) - flea 169
Anorexia 160
Other abnormal test result NOS 145
Digestive tract disorder NOS 143
Lack of efficacy (ectoparasite) - tick NOS 133
INEFFECTIVE, HOOKS 127
Not eating 125
Emesis (multiple) 118
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 737
Milbemycin Oxime + Spinosad 645
Afoxolaner 620
Pyrantel Pamoate;Sarolaner 273
Moxidectin 171
Fluralaner Chew Tablets 167
Milbemycin Oxime + Praziquantel 166
Fluralaner 13.64% 12-Week Chew 143
Spinosad 118
Prednisone 114
Sarolaner 112
Carprofen 102
Bedinvetmab 91
Desoxycorticosterone Pivalate 78
Lotilaner 76
Outcome Breakdown
Recovered/Normal
1,641 (36.8%)
Outcome Unknown
1,616 (36.3%)
Ongoing
980 (22.0%)
Recovered with Sequela
79 (1.8%)
Euthanized
75 (1.7%)
Died
65 (1.5%)
Gender Distribution
Male 2,317 (52.0%)
Female 2,022 (45.4%)
Unknown 102 (2.3%)
Mixed 14 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 48 | |
| 2012 | 226 | |
| 2013 | 274 | |
| 2014 | 254 | |
| 2015 | 279 | |
| 2016 | 332 | |
| 2017 | 384 | |
| 2018 | 327 | |
| 2019 | 373 | |
| 2020 | 344 | |
| 2021 | 325 | |
| 2022 | 277 | |
| 2023 | 374 | |
| 2024 | 405 | |
| 2025 | 230 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #44 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.