Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,326
Total Reports
91
Deaths Reported
690.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 26.6 kg (58.7 lbs)
Top Reported Reactions
Vomiting 318
Lethargy (see also Central nervous system depression in 'Neurological') 171
Emesis 144
Diarrhoea 125
Lack of efficacy - NOS 107
Weight loss 82
Anorexia 62
Decreased appetite 62
Underdose 54
Lack of efficacy (ectoparasite) - flea 53
Not eating 52
INEFFECTIVE, HEARTWORM LARVAE 48
Lack of efficacy (endoparasite) - hookworm 45
Death by euthanasia 45
Behavioural disorder NOS 42
Most Referenced Drugs
Trilostane 372
Milbemycin Oxime + Spinosad 341
Spinosad 79
Pyrantel Pamoate/Praziquantel 63
Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg 55
Carprofen 55
Milbemycin Oxime + Praziquantel 52
Prednisone 47
Verdinexor 40
Ivermectin 272Mcg, Pyrantel 227Mg 34
Milbemycin Oxime, Lufenuron 27
Medetomidine Hydrochloride, Vatinoxan Hydrochloride 26
Nitenpyram 25
Desoxycorticosterone Pivalate 23
Pyrantel Pamoate 22
Outcome Breakdown
Outcome Unknown
556 (41.9%)
Recovered/Normal
530 (39.9%)
Ongoing
114 (8.6%)
Euthanized
51 (3.8%)
Died
40 (3.0%)
Recovered with Sequela
36 (2.7%)
Gender Distribution
Female 655 (49.4%)
Male 642 (48.4%)
Unknown 26 (2.0%)
Mixed 3 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 37 | |
| 2012 | 108 | |
| 2013 | 97 | |
| 2014 | 199 | |
| 2015 | 139 | |
| 2016 | 84 | |
| 2017 | 47 | |
| 2018 | 57 | |
| 2019 | 74 | |
| 2020 | 63 | |
| 2021 | 77 | |
| 2022 | 94 | |
| 2023 | 84 | |
| 2024 | 97 | |
| 2025 | 68 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #92 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.