Total Reports
1,326
FDA CVM filings
Dog /
FDA CVM · 2025 release 1,326 reports on file
American Pit Bull Terrier - FDA Adverse Event Profile
Adverse-event records for American Pit Bull Terrier (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 1,326 reports on file, American Pit Bull Terrier sits at #92 among dog breeds by volume; death-coded share is 6.9% (91 reports).
- #92
- most-reported dog breed
- 6.9%
- death-coded report share
- 318
- Vomiting - top reaction
- 5.5 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
91
of 1,326 reports
Death Rate
6.9%
death-coded share
Avg Age at Report
5.5 yr
26.6 kg avg weight
Death-Coded Outcome Share
American Pit Bull Terrier death-coded reports 6.9%
Cross-breed median
6.9% of 1,326 american pit bull terrier reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 26.6 kg (58.7 lbs)
Top Reported Reactions
Vomiting 318
Lethargy (see also Central nervous system depression in 'Neurological') 171
Emesis 144
Diarrhoea 125
Lack of efficacy - NOS 107
Weight loss 82
Anorexia 62
Decreased appetite 62
Underdose 54
Lack of efficacy (ectoparasite) - flea 53
Not eating 52
INEFFECTIVE, HEARTWORM LARVAE 48
Lack of efficacy (endoparasite) - hookworm 45
Death by euthanasia 45
Behavioural disorder NOS 42
Most Referenced Drugs
Trilostane 372
Milbemycin Oxime + Spinosad 341
Spinosad 79
Pyrantel Pamoate/Praziquantel 63
Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg 55
Carprofen 55
Milbemycin Oxime + Praziquantel 52
Prednisone 47
Verdinexor 40
Ivermectin 272Mcg, Pyrantel 227Mg 34
Milbemycin Oxime, Lufenuron 27
Medetomidine Hydrochloride, Vatinoxan Hydrochloride 26
Nitenpyram 25
Desoxycorticosterone Pivalate 23
Pyrantel Pamoate 22
Outcome Breakdown
Outcome Unknown
556 (41.9%)
Recovered/Normal
530 (39.9%)
Ongoing
114 (8.6%)
Euthanized
51 (3.8%)
Died
40 (3.0%)
Recovered with Sequela
36 (2.7%)
Gender Distribution
Female 655 (49.4%)
Male 642 (48.4%)
Unknown 26 (2.0%)
Mixed 3 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 37 | |
| 2012 | 108 | |
| 2013 | 97 | |
| 2014 | 199 | |
| 2015 | 139 | |
| 2016 | 84 | |
| 2017 | 47 | |
| 2018 | 57 | |
| 2019 | 74 | |
| 2020 | 63 | |
| 2021 | 77 | |
| 2022 | 94 | |
| 2023 | 84 | |
| 2024 | 97 | |
| 2025 | 68 | |
American Pit Bull Terrier Pet Health Insights
American Pit Bull Terrier accounts for 1,326 FDA adverse event reports, ranking #92 by volume among dog breeds, with 91 reports (6.9%) coded as a death outcome. Mean age at report: 5.5 years, average weight 26.6 kg (58.7 lbs).
Top reported signs: Vomiting (318), Lethargy (see also Central nervous system depression in 'Neurological') (171), Emesis (144). Most-referenced drug: Trilostane (372 reports), followed by Milbemycin Oxime + Spinosad (341) and Spinosad (79).
Outcome coding on 1,327 status-recorded reports is dominated by Outcome Unknown (41.9%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve American Pit Bull Terrier? ▼
There are 1,326 adverse event reports involving American Pit Bull Terrier in the FDA database, with 91 reports involving death (6.9% death rate). American Pit Bull Terrier ranks #92 by report volume.
What are the most common adverse reactions reported for American Pit Bull Terrier? ▼
The most commonly reported adverse reactions for American Pit Bull Terrier are Vomiting (318 reports), Lethargy (see also Central nervous system depression in 'Neurological') (171 reports), Emesis (144 reports), Diarrhoea (125 reports), Lack of efficacy - NOS (107 reports).
What drugs are most frequently associated with American Pit Bull Terrier adverse events? ▼
The drugs most frequently referenced in American Pit Bull Terrier adverse event reports are Trilostane (372 reports), Milbemycin Oxime + Spinosad (341 reports), Spinosad (79 reports), Pyrantel Pamoate/Praziquantel (63 reports), Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg (55 reports).
What is the average age of American Pit Bull Terrier in adverse event reports? ▼
The average age of American Pit Bull Terrier at the time of adverse event reports is 5.5 years, with an average weight of 26.6 kg (58.7 lbs).
Does a high number of adverse event reports mean American Pit Bull Terrier is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this American Pit Bull Terrier safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.