Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
90,806
Total Reports
3,311
Deaths Reported
360.0%
Death Rate
5.2 yr
Avg Age at Report
Average weight at time of report: 30.8 kg (67.9 lbs)
Top Reported Reactions
Vomiting 15,438
Lack of efficacy (endoparasite) - heartworm 10,134
INEFFECTIVE, HEARTWORM LARVAE 9,664
Emesis 6,704
Lethargy (see also Central nervous system depression in 'Neurological') 5,869
Lack of efficacy - NOS 5,785
Lack of efficacy (endoparasite) - hookworm 5,726
Diarrhoea 5,554
Digestive tract disorder NOS 3,652
Anorexia 2,928
Seizure NOS 2,849
Cardiac disorder NOS 2,755
INEFFECTIVE, ASCARIDS NOS 2,558
Elevated alanine aminotransferase (ALT) 2,462
Lack of efficacy (ectoparasite) - flea 2,361
Most Referenced Drugs
Milbemycin Oxime + Spinosad 16,498
Ivermectin + Pyrantel As Pamoate Salt 14,668
Moxidectin 5,493
Pyrantel Pamoate;Sarolaner 5,436
Milbemycin Oxime + Praziquantel 5,387
Afoxolaner 5,367
Carprofen 4,267
Spinosad 2,959
Oclacitinib Maleate 2,842
Bedinvetmab 2,783
Fluralaner Chew Tablets 2,581
Fluralaner 13.64% 12-Week Chew 1,782
Ivermectin, Pyrantel 1,766
Sarolaner 1,665
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1,598
Outcome Breakdown
Outcome Unknown
29,183 (34.6%)
Recovered/Normal
23,820 (28.2%)
Ongoing
22,657 (26.9%)
Recovered with Sequela
5,353 (6.3%)
Euthanized
1,687 (2.0%)
Died
1,630 (1.9%)
Gender Distribution
Male 44,733 (49.3%)
Female 44,690 (49.2%)
Unknown 1,169 (1.3%)
Mixed 214 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3,617 | |
| 2011 | 3,906 | |
| 2012 | 5,248 | |
| 2013 | 5,940 | |
| 2014 | 6,188 | |
| 2015 | 6,509 | |
| 2016 | 6,916 | |
| 2017 | 6,945 | |
| 2018 | 6,559 | |
| 2019 | 6,432 | |
| 2020 | 5,957 | |
| 2021 | 5,582 | |
| 2022 | 5,122 | |
| 2023 | 5,321 | |
| 2024 | 6,603 | |
| 2025 | 3,961 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #1 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.