Total Reports
90,806
FDA CVM filings
Dog /
FDA CVM · 2025 release 90,806 reports on file
Retriever - Labrador - FDA Adverse Event Profile
Adverse-event records for Retriever - Labrador (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Retriever - Labrador ranks #1 by report volume among dog breeds - 3,311 of 90,806 reports (3.6%) recorded a death outcome.
- #1
- most-reported dog breed
- 3.6%
- death-coded report share
- 15,438
- Vomiting - top reaction
- 5.2 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
3,311
of 90,806 reports
Death Rate
3.6%
death-coded share
Avg Age at Report
5.2 yr
30.8 kg avg weight
Death-Coded Outcome Share
Retriever - Labrador death-coded reports 3.6%
Cross-breed median
3.6% of 90,806 retriever - labrador reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 30.8 kg (67.9 lbs)
Top Reported Reactions
Vomiting 15,438
Lack of efficacy (endoparasite) - heartworm 10,134
INEFFECTIVE, HEARTWORM LARVAE 9,664
Emesis 6,704
Lethargy (see also Central nervous system depression in 'Neurological') 5,869
Lack of efficacy - NOS 5,785
Lack of efficacy (endoparasite) - hookworm 5,726
Diarrhoea 5,554
Digestive tract disorder NOS 3,652
Anorexia 2,928
Seizure NOS 2,849
Cardiac disorder NOS 2,755
INEFFECTIVE, ASCARIDS NOS 2,558
Elevated alanine aminotransferase (ALT) 2,462
Lack of efficacy (ectoparasite) - flea 2,361
Most Referenced Drugs
Milbemycin Oxime + Spinosad 16,498
Ivermectin + Pyrantel As Pamoate Salt 14,668
Moxidectin 5,493
Pyrantel Pamoate;Sarolaner 5,436
Milbemycin Oxime + Praziquantel 5,387
Afoxolaner 5,367
Carprofen 4,267
Spinosad 2,959
Oclacitinib Maleate 2,842
Bedinvetmab 2,783
Fluralaner Chew Tablets 2,581
Fluralaner 13.64% 12-Week Chew 1,782
Ivermectin, Pyrantel 1,766
Sarolaner 1,665
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1,598
Outcome Breakdown
Outcome Unknown
29,183 (34.6%)
Recovered/Normal
23,820 (28.2%)
Ongoing
22,657 (26.9%)
Recovered with Sequela
5,353 (6.3%)
Euthanized
1,687 (2.0%)
Died
1,630 (1.9%)
Gender Distribution
Male 44,733 (49.3%)
Female 44,690 (49.2%)
Unknown 1,169 (1.3%)
Mixed 214 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3,617 | |
| 2011 | 3,906 | |
| 2012 | 5,248 | |
| 2013 | 5,940 | |
| 2014 | 6,188 | |
| 2015 | 6,509 | |
| 2016 | 6,916 | |
| 2017 | 6,945 | |
| 2018 | 6,559 | |
| 2019 | 6,432 | |
| 2020 | 5,957 | |
| 2021 | 5,582 | |
| 2022 | 5,122 | |
| 2023 | 5,321 | |
| 2024 | 6,603 | |
| 2025 | 3,961 | |
Retriever - Labrador Pet Health Insights
Retriever - Labrador accounts for 90,806 FDA adverse event reports, ranking #1 by volume among dog breeds, with 3,311 reports (3.6%) coded as a death outcome. Mean age at report: 5.2 years, average weight 30.8 kg (67.9 lbs).
Top reported signs: Vomiting (15,438), Lack of efficacy (endoparasite) - heartworm (10,134), INEFFECTIVE, HEARTWORM LARVAE (9,664). Most-referenced drug: Milbemycin Oxime + Spinosad (16,498 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (14,668) and Moxidectin (5,493).
Outcome coding on 84,330 status-recorded reports is dominated by Outcome Unknown (34.6%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Crossbred Canine/dog
68,210 reports · 3.2% death rate
Dog (unknown)
47,381 reports · 8.7% death rate
Retriever - Golden
34,475 reports · 3.7% death rate
Shepherd Dog - German
31,142 reports · 4.3% death rate
Chihuahua
30,657 reports · 4.2% death rate
Terrier - Yorkshire
24,408 reports · 3.7% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Retriever - Labrador? ▼
There are 90,806 adverse event reports involving Retriever - Labrador in the FDA database, with 3,311 reports involving death (3.6% death rate). Retriever - Labrador ranks #1 by report volume.
What are the most common adverse reactions reported for Retriever - Labrador? ▼
The most commonly reported adverse reactions for Retriever - Labrador are Vomiting (15,438 reports), Lack of efficacy (endoparasite) - heartworm (10,134 reports), INEFFECTIVE, HEARTWORM LARVAE (9,664 reports), Emesis (6,704 reports), Lethargy (see also Central nervous system depression in 'Neurological') (5,869 reports).
What drugs are most frequently associated with Retriever - Labrador adverse events? ▼
The drugs most frequently referenced in Retriever - Labrador adverse event reports are Milbemycin Oxime + Spinosad (16,498 reports), Ivermectin + Pyrantel As Pamoate Salt (14,668 reports), Moxidectin (5,493 reports), Pyrantel Pamoate;Sarolaner (5,436 reports), Milbemycin Oxime + Praziquantel (5,387 reports).
What is the average age of Retriever - Labrador in adverse event reports? ▼
The average age of Retriever - Labrador at the time of adverse event reports is 5.2 years, with an average weight of 30.8 kg (67.9 lbs).
Does a high number of adverse event reports mean Retriever - Labrador is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Retriever - Labrador safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.