Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
564
Total Reports
11
Deaths Reported
200.0%
Death Rate
3.7 yr
Avg Age at Report
Average weight at time of report: 26.3 kg (58.0 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 161
Vomiting 80
Lack of efficacy (ectoparasite) - flea 41
Lack of efficacy (endoparasite) - hookworm 34
INEFFECTIVE, HEARTWORM LARVAE 33
Lethargy (see also Central nervous system depression in 'Neurological') 29
Diarrhoea 25
Emesis 24
Drug dose omission 23
INEFFECTIVE, HOOKS 22
Lack of efficacy - NOS 20
Overdose 16
Seizure NOS 14
Not eating 12
Underdose 11
Most Referenced Drugs
Milbemycin Oxime + Spinosad 156
Moxidectin 84
Pyrantel Pamoate;Sarolaner 71
Milbemycin Oxime + Praziquantel 53
Ivermectin + Pyrantel As Pamoate Salt 46
Spinosad 26
Oclacitinib Maleate 17
Melarsomine Dihydrochloride 16
Ivermectin + Praziquantel + Pyrantel Pamoate 15
Ivermectin 14
Fluralaner 13.64% 12-Week Chew 14
Afoxolaner 13
Ivermectin + Pyrantel 12
Sarolaner 11
Bedinvetmab 10
Outcome Breakdown
Outcome Unknown
209 (37.1%)
Ongoing
203 (36.0%)
Recovered/Normal
115 (20.4%)
Recovered with Sequela
26 (4.6%)
Died
7 (1.2%)
Euthanized
4 (0.7%)
Gender Distribution
Female 285 (50.5%)
Male 276 (48.9%)
Unknown 3 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 13 | |
| 2013 | 16 | |
| 2014 | 14 | |
| 2015 | 33 | |
| 2016 | 28 | |
| 2017 | 27 | |
| 2018 | 52 | |
| 2019 | 60 | |
| 2020 | 46 | |
| 2021 | 56 | |
| 2022 | 70 | |
| 2023 | 57 | |
| 2024 | 43 | |
| 2025 | 49 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #132 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.