Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,210
Total Reports
36
Deaths Reported
300.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 28.2 kg (62.2 lbs)
Top Reported Reactions
Vomiting 167
Lack of efficacy (endoparasite) - heartworm 160
Lack of efficacy (endoparasite) - hookworm 117
INEFFECTIVE, HEARTWORM LARVAE 79
Diarrhoea 69
Lethargy (see also Central nervous system depression in 'Neurological') 68
Emesis 62
Lack of efficacy - NOS 55
Lack of efficacy (ectoparasite) - tick NOS 55
INEFFECTIVE, HOOKS 52
Lack of efficacy (ectoparasite) - flea 38
Lack of efficacy (endoparasite) - roundworm NOS 33
Seizure NOS 31
Digestive tract disorder NOS 27
Lack of efficacy (bacteria) - NOS 27
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 165
Milbemycin Oxime + Spinosad 131
Pyrantel Pamoate;Sarolaner 109
Moxidectin 104
Fluralaner Chew Tablets 88
Milbemycin Oxime + Praziquantel 78
Fluralaner 13.64% 12-Week Chew 57
Oclacitinib Maleate 51
Spinosad 47
Ivermectin, Pyrantel 36
Sarolaner 35
Ivermectin + Pyrantel 32
Carprofen 30
Afoxolaner 28
Melarsomine Dihydrochloride 26
Outcome Breakdown
Ongoing
446 (40.6%)
Outcome Unknown
324 (29.5%)
Recovered/Normal
249 (22.7%)
Recovered with Sequela
43 (3.9%)
Died
20 (1.8%)
Euthanized
16 (1.5%)
Gender Distribution
Male 615 (50.8%)
Female 570 (47.1%)
Unknown 20 (1.7%)
Mixed 5 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 70 | |
| 2011 | 55 | |
| 2012 | 39 | |
| 2013 | 43 | |
| 2014 | 40 | |
| 2015 | 53 | |
| 2016 | 76 | |
| 2017 | 89 | |
| 2018 | 94 | |
| 2019 | 103 | |
| 2020 | 104 | |
| 2021 | 105 | |
| 2022 | 95 | |
| 2023 | 88 | |
| 2024 | 99 | |
| 2025 | 57 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #100 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.