Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
149
Total Reports
4
Deaths Reported
270.0%
Death Rate
6.5 yr
Avg Age at Report
Average weight at time of report: 9.8 kg (21.6 lbs)
Top Reported Reactions
Vomiting 38
Diarrhoea 17
Lethargy (see also Central nervous system depression in 'Neurological') 13
Lack of efficacy (endoparasite) - hookworm 12
Emesis 11
Digestive tract disorder NOS 9
Lack of efficacy - NOS 8
Ataxia 7
Anorexia 5
Lack of efficacy (ectoparasite) - tick NOS 5
INEFFECTIVE, HEARTWORM LARVAE 4
Elevated liver enzymes 4
Skin disorders NOS 4
Shaking 4
Dehydration 3
Most Referenced Drugs
Milbemycin Oxime + Spinosad 30
Ivermectin + Pyrantel As Pamoate Salt 14
Afoxolaner 13
Fluralaner Chew Tablets 12
Spinosad 7
Pyrantel Pamoate;Sarolaner 6
Trilostane 5
Sarolaner 5
Ivermectin, Pyrantel 4
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 4
Oclacitinib Maleate 4
Afoxolaner 28.3 Mg Chewable Tablets 4
Cyclosporine 3
Milbemycin Oxime 3
Meloxicam 3
Outcome Breakdown
Recovered/Normal
61 (45.2%)
Outcome Unknown
47 (34.8%)
Ongoing
17 (12.6%)
Recovered with Sequela
6 (4.4%)
Died
3 (2.2%)
Euthanized
1 (0.7%)
Gender Distribution
Female 78 (52.3%)
Male 69 (46.3%)
Unknown 2 (1.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 11 | |
| 2012 | 15 | |
| 2013 | 6 | |
| 2014 | 12 | |
| 2015 | 15 | |
| 2016 | 16 | |
| 2017 | 13 | |
| 2018 | 7 | |
| 2019 | 12 | |
| 2020 | 8 | |
| 2021 | 6 | |
| 2022 | 4 | |
| 2023 | 11 | |
| 2024 | 5 | |
| 2025 | 5 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #207 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.